Probing protease activity by single-fluorescent-protein nanocapsules

Zhen Gu, Anuradha Biswas, Kye Il Joo, Biliang Hu, Pin Wang, Yi Tang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


We describe a FRET-based protease detection strategy, using a single-fluorescent-protein nanogel as donor and a dark quencher as acceptor linked by a photolabile caged-peptide. This design enables probing of protease activity in a UV-responsive fashion.

Original languageEnglish
Pages (from-to)6467-6469
Number of pages3
JournalChemical Communications
Issue number35
StatePublished - 21 Sep 2010


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