Pro-inflammatory cytokine expression of spleen dendritic cells in mouse toxoplasmosis

Ho Woo Nam, Hye Jin Ahn, Hyun Jong Yang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1α, IL-1β, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8α+/ CD11c+ splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalThe Korean journal of parasitology
Issue number2
StatePublished - Jun 2011


  • Cytokine
  • Dendritic cell
  • FACS
  • Mouse
  • Spleen
  • Toxoplasma gondii


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