Primo Vascular System of Murine Melanoma and Heterogeneity of Tissue Oxygenation of the Melanoma

Minyoung Hong; Sarah S. Park; Hyunkyung Do; Gil ja Jhon; Minah Suh; Youngmi Lee

doi:10.1016/j.jams.2011.09.002

Primo Vascular System of Murine Melanoma and Heterogeneity of Tissue Oxygenation of the Melanoma

Minyoung Hong, Sarah S. Park, Hyunkyung Do, Gil ja Jhon, Minah Suh, Youngmi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Murine melanoma requires the complex development of lymphatic, vascular, and non-vascular structures. A possible relationship between the primo vascular system (PVS) and the melanoma metastasis has been proposed. In particular, the PVS may be involved in oxygen transport. Vasculogenic-like networks, similar to the PVS, have been found within melanoma tumors, but their functional relationship with the PVS and meridian structures are unclear. Herein, we report on the use of an electrochemical O₂ sensor to study oxygenation levels of melanoma tumors in mice. We consistently found higher tissue oxygenation in specific sites of tumors (n=5). These sites were strongly associated with vascular structures or the PVS. Furthermore, the PVS on the tumor surface was associated with adipose tissue. Our findings suggest that the PVS is involved in the regulation of metastasis.

Original language	English
Pages (from-to)	159-163
Number of pages	5
Journal	JAMS Journal of Acupuncture and Meridian Studies
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.jams.2011.09.002
State	Published - Sep 2011

Bibliographical note

Funding Information:
This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number 2010K001391 ).

Keywords

Biosensor
Melanoma
Primo vascular system
Vasculogenic mimicry

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title = "Primo Vascular System of Murine Melanoma and Heterogeneity of Tissue Oxygenation of the Melanoma",

abstract = "Murine melanoma requires the complex development of lymphatic, vascular, and non-vascular structures. A possible relationship between the primo vascular system (PVS) and the melanoma metastasis has been proposed. In particular, the PVS may be involved in oxygen transport. Vasculogenic-like networks, similar to the PVS, have been found within melanoma tumors, but their functional relationship with the PVS and meridian structures are unclear. Herein, we report on the use of an electrochemical O2 sensor to study oxygenation levels of melanoma tumors in mice. We consistently found higher tissue oxygenation in specific sites of tumors (n=5). These sites were strongly associated with vascular structures or the PVS. Furthermore, the PVS on the tumor surface was associated with adipose tissue. Our findings suggest that the PVS is involved in the regulation of metastasis.",

keywords = "Biosensor, Melanoma, Primo vascular system, Vasculogenic mimicry",

author = "Minyoung Hong and Park, {Sarah S.} and Hyunkyung Do and Jhon, {Gil ja} and Minah Suh and Youngmi Lee",

note = "Funding Information: This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number 2010K001391 ).",

year = "2011",

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doi = "10.1016/j.jams.2011.09.002",

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AU - Hong, Minyoung

AU - Park, Sarah S.

AU - Do, Hyunkyung

AU - Jhon, Gil ja

AU - Suh, Minah

AU - Lee, Youngmi

N1 - Funding Information: This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number 2010K001391 ).

PY - 2011/9

Y1 - 2011/9

N2 - Murine melanoma requires the complex development of lymphatic, vascular, and non-vascular structures. A possible relationship between the primo vascular system (PVS) and the melanoma metastasis has been proposed. In particular, the PVS may be involved in oxygen transport. Vasculogenic-like networks, similar to the PVS, have been found within melanoma tumors, but their functional relationship with the PVS and meridian structures are unclear. Herein, we report on the use of an electrochemical O2 sensor to study oxygenation levels of melanoma tumors in mice. We consistently found higher tissue oxygenation in specific sites of tumors (n=5). These sites were strongly associated with vascular structures or the PVS. Furthermore, the PVS on the tumor surface was associated with adipose tissue. Our findings suggest that the PVS is involved in the regulation of metastasis.

AB - Murine melanoma requires the complex development of lymphatic, vascular, and non-vascular structures. A possible relationship between the primo vascular system (PVS) and the melanoma metastasis has been proposed. In particular, the PVS may be involved in oxygen transport. Vasculogenic-like networks, similar to the PVS, have been found within melanoma tumors, but their functional relationship with the PVS and meridian structures are unclear. Herein, we report on the use of an electrochemical O2 sensor to study oxygenation levels of melanoma tumors in mice. We consistently found higher tissue oxygenation in specific sites of tumors (n=5). These sites were strongly associated with vascular structures or the PVS. Furthermore, the PVS on the tumor surface was associated with adipose tissue. Our findings suggest that the PVS is involved in the regulation of metastasis.

KW - Biosensor

KW - Melanoma

KW - Primo vascular system

KW - Vasculogenic mimicry

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Primo Vascular System of Murine Melanoma and Heterogeneity of Tissue Oxygenation of the Melanoma

Abstract

Bibliographical note

Keywords

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