Primo Vascular System of Murine Melanoma and Heterogeneity of Tissue Oxygenation of the Melanoma

Minyoung Hong, Sarah S. Park, Hyunkyung Do, Gil ja Jhon, Minah Suh, Youngmi Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Murine melanoma requires the complex development of lymphatic, vascular, and non-vascular structures. A possible relationship between the primo vascular system (PVS) and the melanoma metastasis has been proposed. In particular, the PVS may be involved in oxygen transport. Vasculogenic-like networks, similar to the PVS, have been found within melanoma tumors, but their functional relationship with the PVS and meridian structures are unclear. Herein, we report on the use of an electrochemical O2 sensor to study oxygenation levels of melanoma tumors in mice. We consistently found higher tissue oxygenation in specific sites of tumors (n=5). These sites were strongly associated with vascular structures or the PVS. Furthermore, the PVS on the tumor surface was associated with adipose tissue. Our findings suggest that the PVS is involved in the regulation of metastasis.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalJAMS Journal of Acupuncture and Meridian Studies
Issue number3
StatePublished - Sep 2011

Bibliographical note

Funding Information:
This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number 2010K001391 ).


  • Biosensor
  • Melanoma
  • Primo vascular system
  • Vasculogenic mimicry


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