Primary cilia as a signaling platform for control of energy metabolism

Do Kyeong Song, Jong Han Choi, Min Seon Kim

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity. Recent studies have demonstrated involvement of cilia-related cellular signaling pathways in transducing metabolic information in hypothalamic neurons and in determining cellular fate during adipose tissue development. In this review, we summarize the current knowledge about cilia and cilia-associated signaling pathways in the regulation of body metabolism.

Original languageEnglish
Pages (from-to)117-127
Number of pages11
JournalDiabetes and Metabolism Journal
Volume42
Issue number2
DOIs
StatePublished - 1 Apr 2018

Keywords

  • Cilia
  • Hedgehogs
  • Metabolism
  • Obesity
  • Wnt signaling pathway

Fingerprint

Dive into the research topics of 'Primary cilia as a signaling platform for control of energy metabolism'. Together they form a unique fingerprint.

Cite this