Primary chest wall sarcoma: Surgical outcomes and prognostic factors

Ilkun Park; Sumin Shin; Hong Kwan Kim; Yong Soo Choi; Jhingook Kim; Jae Ill Zo; Young Mog Shim; Jong Ho Cho

doi:10.5090/kjtcs.2019.52.5.360

Primary chest wall sarcoma: Surgical outcomes and prognostic factors

Ilkun Park, Sumin Shin, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Jong Ho Cho

Department of Thoraxic and Cardiovascular Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Primary chest wall sarcoma is a rare disease with limited reports of surgical resection. Methods: This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence- free survival (RFS). Results: The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence. Conclusion: Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.

Original language	English
Pages (from-to)	360-367
Number of pages	8
Journal	Korean Journal of Thoracic and Cardiovascular Surgery
Volume	52
Issue number	5
DOIs	https://doi.org/10.5090/kjtcs.2019.52.5.360
State	Published - 2019

Bibliographical note

Funding Information:
This study was supported by a Grant of the Samsung Vein Clinic Network (Daejeon, Anyang, Cheongju, Cheonan; Fund no. KTCS04-127).

Publisher Copyright:
© 2019, The Korean Society for Thoracic and Cardiovascular Surgery.

Keywords

Chest wall
Sarcoma
Undifferentiated pleomorphic sarcoma

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10.5090/kjtcs.2019.52.5.360

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title = "Primary chest wall sarcoma: Surgical outcomes and prognostic factors",

abstract = "Background: Primary chest wall sarcoma is a rare disease with limited reports of surgical resection. Methods: This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence- free survival (RFS). Results: The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence. Conclusion: Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.",

keywords = "Chest wall, Sarcoma, Undifferentiated pleomorphic sarcoma",

author = "Ilkun Park and Sumin Shin and Kim, {Hong Kwan} and Choi, {Yong Soo} and Jhingook Kim and Zo, {Jae Ill} and Shim, {Young Mog} and Cho, {Jong Ho}",

note = "Funding Information: This study was supported by a Grant of the Samsung Vein Clinic Network (Daejeon, Anyang, Cheongju, Cheonan; Fund no. KTCS04-127). Publisher Copyright: {\textcopyright} 2019, The Korean Society for Thoracic and Cardiovascular Surgery.",

year = "2019",

doi = "10.5090/kjtcs.2019.52.5.360",

language = "English",

volume = "52",

pages = "360--367",

journal = "Korean Journal of Thoracic and Cardiovascular Surgery",

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TY - JOUR

T1 - Primary chest wall sarcoma

T2 - Surgical outcomes and prognostic factors

AU - Park, Ilkun

AU - Shin, Sumin

AU - Kim, Hong Kwan

AU - Choi, Yong Soo

AU - Kim, Jhingook

AU - Zo, Jae Ill

AU - Shim, Young Mog

AU - Cho, Jong Ho

N1 - Funding Information: This study was supported by a Grant of the Samsung Vein Clinic Network (Daejeon, Anyang, Cheongju, Cheonan; Fund no. KTCS04-127). Publisher Copyright: © 2019, The Korean Society for Thoracic and Cardiovascular Surgery.

PY - 2019

Y1 - 2019

N2 - Background: Primary chest wall sarcoma is a rare disease with limited reports of surgical resection. Methods: This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence- free survival (RFS). Results: The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence. Conclusion: Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.

AB - Background: Primary chest wall sarcoma is a rare disease with limited reports of surgical resection. Methods: This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence- free survival (RFS). Results: The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence. Conclusion: Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.

KW - Chest wall

KW - Sarcoma

KW - Undifferentiated pleomorphic sarcoma

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JO - Korean Journal of Thoracic and Cardiovascular Surgery

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Primary chest wall sarcoma: Surgical outcomes and prognostic factors

Abstract

Bibliographical note

Keywords

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