Preventive effects of ulinastatin on post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: A prospective, randomized, placebo-controlled trial

Ji Won Yoo, Ji Kon Ryu, Sang Hyub Lee, Sang Myung Woo, Joo Kyung Park, Won Jae Yoon, Jun Kyu Lee, Kwang Hyuck Lee, Jin Hyeok Hwang, Yong Tae Kim, Yong Bum Yoon

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

OBJECTIVES:: Previous studies have shown that ulinastatin may be effective at preventing pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). However, routine administration of ulinastatin is unlikely to be cost-effective. So the aim of this prospective study was to evaluate the effectiveness of low-dose ulinastatin at preventing pancreatitis in patients at high risk of post-ERCP pancreatitis. METHODS:: A total of 227 patients (mean age, 63 years; 54% men) were randomized to receive placebo (n = 108) or active drug (n = 119) immediately after ERCP and received active drug (100,000 U of ulinastatin) or placebo. Occurrence of post-ERCP pancreatitis and hyperamylasemia were compared between the 2 groups. RESULTS:: The overall incidence of pancreatitis was 6.2%, and no significant differences were observed between placebo- and ulinastatin-treated patients in terms of the frequencies of pancreatitis (5.6% vs 6.7%), abdominal pain, or hyperamylasemia. Pancreatic duct acinarization, papillectomy of ampulla of Vater adenoma, difficult cannulation, and female sex were identified as risk factors for pancreatitis in univariate analysis. CONCLUSIONS:: Low-dose prophylactic treatment with ulinastatin immediately after ERCP did not show a beneficial influence on the incidence of post-ERCP pancreatitis and hyperamylasemia in high-risk patients.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalPancreas
Volume37
Issue number4
DOIs
StatePublished - Nov 2008

Keywords

  • Hyperamylasemia
  • Pancreatitis
  • Prophylaxis
  • Trypsin inhibitor
  • Ulinastatin

Fingerprint

Dive into the research topics of 'Preventive effects of ulinastatin on post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: A prospective, randomized, placebo-controlled trial'. Together they form a unique fingerprint.

Cite this