Preventive effect of residential green space on infantile atopic dermatitis associated with prenatal air pollution exposure

Ji Young Lee, Dirga Kumar Lamichhane, Myeongjee Lee, Shinhee Ye, Jung Hyun Kwon, Myung Sook Park, Hwan Cheol Kim, Jong Han Leem, Yun Chul Hong, Yangho Kim, Mina Ha, Eunhee Ha

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39 Scopus citations


Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO2 ) and particulate matter with an aerodynamic diameter of <10 µm (PM10 ) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to examine how this association changes with residential green space. This study used prospective data from 659 participants of the Mothers and Children’s Environmental Health study. Subjects were geocoded to their residential addresses and matched with air pollution data modeled using land-use regression. Information on infantile AD was obtained by using a questionnaire administered to the parents or guardians of the children. The association between infantile AD and exposure to NO2 and PM10 was determined using logistic regression models. We assessed the effects of residential green spaces using stratified analyses and by entering product terms into the logistic regression models. The risk of infantile AD significantly increased with an increase in air pollution exposure during the first trimester of pregnancy. The adjusted odds ratio (OR) and 95% confidence interval (CI) were 1.219 (1.023–1.452) per 10 µg/m3 increase in PM10 and 1.353 (1.027–1.782) per 10 ppb increase in NO2. An increase in the green space within 200 m of residence was associated with a decreased risk of AD (OR = 0.996, 95% CI: 0.993–0.999). The stratified analysis of residential green space revealed stronger associations between infantile AD and PM10 and NO2 exposure during the first trimester in the areas in the lower tertiles of green space. This study indicated that exposure to TRAP during the first trimester of pregnancy is associated with infantile AD. Less residential green space may intensify the association between TRAP exposure and infantile AD.

Original languageEnglish
Article number102
JournalInternational Journal of Environmental Research and Public Health
Issue number1
StatePublished - 9 Jan 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.


  • Atopic dermatitis
  • Birth cohort
  • Child health
  • Greenness
  • Particulate matter
  • Traffic-related air pollution


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