Prevalence of human papilloma virus infections and cervical cytological abnormalities among Korean women with systemic lupus erythematosus

You Hyun Lee, Jung Yoon Choe, Sung Hoon Park, Yong Wook Park, Shin Seok Lee, Young Mo Kang, Eon Jeong Nam, Won Park, Seong Ryul Kwon, Sang Cheol Bae, Yun Jung Kim, Chang Hee Suh, Hyoun Ah Kim, Nam Wook Hur, Jisoo Lee

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

We performed a multicenter cross-sectional study of 134 sexually active systemic lupus erythematosus (SLE) patients to investigate the prevalence of and risk factors for high risk human papilloma virus (HPV) infection and cervical cytological abnormalities among Korean women with SLE. In this multicenter cross-sectional study, HPV testing and routine cervical cytologic examination was performed. HPV was typed using a hybrid method or the polymerase chain reaction. Data on 4,595 healthy women were used for comparison. SLE patients had greater prevalence of high-risk HPV infection (24.6% vs. 7.9%, P<0.001, odds ratio 3.8, 95% confidence interval 2.5-5.7) and of abnormal cervical cytology (16.4 vs. 2.8%, P<0.001, OR 4.4, 95% CI 2.5-7.8) compared with controls. SLE itself was identified as independent risk factors for high risk HPV infection among Korean women (OR 3.8, 95% CI 2.5-5.7) along with ≥2 sexual partners (OR 8.5, 95% CI 1.2-61.6), and Pap smear abnormalities (OR 97.3, 95% CI 6.5-1,456.7). High-risk HPV infection and cervical cytological abnormalities were more common among Korean women with SLE than controls. SLE itself may be a risk factor for HPV infection among Korean women, suggesting the importance of close monitoring of HPV infections and abnormal Pap smears in SLE patients.

Original languageEnglish
Pages (from-to)1431-1437
Number of pages7
JournalJournal of Korean Medical Science
Volume25
Issue number10
DOIs
StatePublished - Oct 2010

Keywords

  • Cervical cytological abnormalities
  • Human papilloma virus
  • Systemic lupus erythematosus

Fingerprint

Dive into the research topics of 'Prevalence of human papilloma virus infections and cervical cytological abnormalities among Korean women with systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this