TY - JOUR
T1 - Prevalence of Barrett's esophagus remains low in the korean population
T2 - Nationwide cross-sectional prospective multicenter study
AU - Lee, In Seok
AU - Choi, Suck Chei
AU - Shim, Ki Nam
AU - Jee, Sam Ryong
AU - Huh, Kyu Chan
AU - Lee, Jun Haeng
AU - Lee, Kwang Jae
AU - Park, Hyung Seok
AU - Lee, Yong Chan
AU - Jung, Hoon Yong
AU - Park, Hyo Jin
N1 - Funding Information:
Acknowledgments We thank Eunyoung Kim for data management. This work was funded by grants from The Korean Society of Neurogastroenterology and Motility Jeil Pharm. Co., SK Pharm. Co., and Astra Zeneca Pharm. Co.
PY - 2010/7
Y1 - 2010/7
N2 - Purpose: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95% CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. Conclusions: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.
AB - Purpose: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95% CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. Conclusions: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.
KW - Barrett's esophagus
KW - Gastroesophageal reflux
KW - Korean
KW - Prevalence
KW - Reflux esophagitis
UR - http://www.scopus.com/inward/record.url?scp=77954426270&partnerID=8YFLogxK
U2 - 10.1007/s10620-009-0984-0
DO - 10.1007/s10620-009-0984-0
M3 - Article
C2 - 19798574
AN - SCOPUS:77954426270
SN - 0163-2116
VL - 55
SP - 1932
EP - 1939
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 7
ER -