Presence of human mycoplasma DNA in gastric tissue samples from Korean chronic gastritis patients

Hyuk Joon Kwon, Jeong Ok Kang, Sun Hee Cho, Hee Bum Kang, Kyung Ah Kang, Jeong Ki Kim, Yoon Suk Kang, Byung Cheol Song, Hyun Wook Kang, Mi Ja Shim, Hee Sun Kim, Young Bae Kim, Ki Baeg Hahm, Bum Joon Kim, Myeong Cherl Kook, Myung Hee Chung, Jin Won Hyun

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We aimed to determine whether mycoplasmas are present in Korean chronic gastritis, and to understand their roles in gastric cancer tumorigenesis, because mycoplasmas resemble Helicobacter pylori in terms of ammonia production and induction of inflammatory cytokines in immune and non-immune cells. The presence and identity of mycoplasmas were assessed by semi-nested PCR and sequencing, and the results were compared with pathologic data. Fifty-six samples collected from Korean chronic gastritis patients were used for this study. Twenty-three (41.1%) were positive for mycoplasmas. Eighteen sequenced samples contained a single human mycoplasma or two mycoplasmas, which were identified as Mycoplasma faucium (13/18), M. fermentans (3/18), M. orale (1/18), M. salivarium (2/18), and M. spermatophilum (1/ 18). Mycoplasma-infected chronic gastritis samples showed significantly more severe neutrophil infiltration than non-infected samples (P=0.0135). Mycoplasma profiles in the oral cavity (M. salivarium is major) and stomach were different, and the presence of significant proinflammatory responses in mycoplasma-positive patients suggests that the mycoplasmas are not simply contaminants. Further studies are required to understand whether mycoplasmas play a role in gastric tumorigenesis.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalCancer Science
Volume95
Issue number4
DOIs
StatePublished - Apr 2004

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