Prefrontal White Matter Abnormalities Associated With Pain Catastrophizing in Patients With Complex Regional Pain Syndrome

Jooyeon Jamie Im; Jungyoon Kim; Hyeonseok Jeong; Jin Kyoung Oh; Suji Lee; In Kyoon Lyoo; Yong An Chung; Sujung Yoon

doi:10.1016/j.apmr.2020.07.006

Prefrontal White Matter Abnormalities Associated With Pain Catastrophizing in Patients With Complex Regional Pain Syndrome

Jooyeon Jamie Im, Jungyoon Kim, Hyeonseok Jeong, Jin Kyoung Oh, Suji Lee, In Kyoon Lyoo, Yong An Chung, Sujung Yoon

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objective: To investigate altered prefrontal white matter integrity in complex regional pain syndrome (CRPS) and its relation with the degree of pain catastrophizing. Design: Cross-sectional study. Setting: University hospital. Participants: Twenty-one CRPS patients and 49 patients without CRPS (N=70). Interventions: Not applicable. Main Outcome Measures: The fractional anisotropy values within the prefrontal regions reflecting the structural integrity of white matter were measured in CRPS patients and patients without CRPS using diffusion tensor imaging. The degree of pain catastrophizing was also evaluated in CRPS patients. Results: The structural integrity of the prefrontal white matter was lower in CRPS patients than in patients without CRPS (P=.03). In addition, lower structural integrity in the prefrontal cortex was correlated with a higher degree of pain catastrophizing among CRPS patients (r= −0.54, P=.01). Conclusions: Our findings suggest that pain catastrophizing, which is frequently reported in patients with CRPS, may be associated with the dysfunction of the prefrontal white matter.

Original language	English
Pages (from-to)	216-224
Number of pages	9
Journal	Archives of Physical Medicine and Rehabilitation
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.apmr.2020.07.006
State	Published - Feb 2021

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Publisher Copyright:
© 2020 American Congress of Rehabilitation Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

Catastrophizing
Complex regional pain syndrome
Diffusion tensor imaging
Prefrontal cortex
Rehabilitation
White matter

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10.1016/j.apmr.2020.07.006

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title = "Prefrontal White Matter Abnormalities Associated With Pain Catastrophizing in Patients With Complex Regional Pain Syndrome",

abstract = "Objective: To investigate altered prefrontal white matter integrity in complex regional pain syndrome (CRPS) and its relation with the degree of pain catastrophizing. Design: Cross-sectional study. Setting: University hospital. Participants: Twenty-one CRPS patients and 49 patients without CRPS (N=70). Interventions: Not applicable. Main Outcome Measures: The fractional anisotropy values within the prefrontal regions reflecting the structural integrity of white matter were measured in CRPS patients and patients without CRPS using diffusion tensor imaging. The degree of pain catastrophizing was also evaluated in CRPS patients. Results: The structural integrity of the prefrontal white matter was lower in CRPS patients than in patients without CRPS (P=.03). In addition, lower structural integrity in the prefrontal cortex was correlated with a higher degree of pain catastrophizing among CRPS patients (r= −0.54, P=.01). Conclusions: Our findings suggest that pain catastrophizing, which is frequently reported in patients with CRPS, may be associated with the dysfunction of the prefrontal white matter.",

keywords = "Catastrophizing, Complex regional pain syndrome, Diffusion tensor imaging, Prefrontal cortex, Rehabilitation, White matter",

author = "Im, {Jooyeon Jamie} and Jungyoon Kim and Hyeonseok Jeong and Oh, {Jin Kyoung} and Suji Lee and Lyoo, {In Kyoon} and Chung, {Yong An} and Sujung Yoon",

note = "Publisher Copyright: {\textcopyright} 2020 American Congress of Rehabilitation Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

year = "2021",

month = feb,

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AU - Im, Jooyeon Jamie

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AU - Oh, Jin Kyoung

AU - Lee, Suji

AU - Lyoo, In Kyoon

AU - Chung, Yong An

AU - Yoon, Sujung

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AB - Objective: To investigate altered prefrontal white matter integrity in complex regional pain syndrome (CRPS) and its relation with the degree of pain catastrophizing. Design: Cross-sectional study. Setting: University hospital. Participants: Twenty-one CRPS patients and 49 patients without CRPS (N=70). Interventions: Not applicable. Main Outcome Measures: The fractional anisotropy values within the prefrontal regions reflecting the structural integrity of white matter were measured in CRPS patients and patients without CRPS using diffusion tensor imaging. The degree of pain catastrophizing was also evaluated in CRPS patients. Results: The structural integrity of the prefrontal white matter was lower in CRPS patients than in patients without CRPS (P=.03). In addition, lower structural integrity in the prefrontal cortex was correlated with a higher degree of pain catastrophizing among CRPS patients (r= −0.54, P=.01). Conclusions: Our findings suggest that pain catastrophizing, which is frequently reported in patients with CRPS, may be associated with the dysfunction of the prefrontal white matter.

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Prefrontal White Matter Abnormalities Associated With Pain Catastrophizing in Patients With Complex Regional Pain Syndrome

Abstract

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