Prefrontal cortical thickness deficit in detoxified alcohol-dependent patients

Sujin Bae, Ilhyang Kang, Boung Chul Lee, Yujin Jeon, Han Byul Cho, Sujung Yoon, Soo Mee Lim, Jungyoon Kim, In Kyoon Lyoo, Jieun E. Kim, Ihn Geun Choi

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13 Scopus citations


Alcohol dependence is a serious disorder that can be related with a number of potential health-related and social consequences. Cortical thickness measurements would provide important information on the cortical structural alterations in patients with alcohol dependence. Twenty-one patients with alcohol dependence and 22 healthy comparison subjects have been recruited and underwent high-resolution brain magnetic resonance (MR) imaging and clinical assessments. T1-weighted MR images were analyzed using the cortical thickness analysis program. Significantly thinner cortical thickness in patients with alcohol dependence than healthy comparison subjects was noted in the left superior frontal cortical region, correcting for multiple comparisons and adjusting with age and hemispheric average cortical thickness. There was a significant association between thickness in the cluster of the left superior frontal cortex and the duration of alcohol use. The prefrontal cortical region may particularly be vulnerable to chronic alcohol exposure. It is also possible that the pre-existing deficit in this region may have rendered individuals more susceptible to alcohol dependence.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalExperimental Neurobiology
Issue number6
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© Experimental Neurobiology 2017.


  • Alcoholism
  • Cerebral Cortex
  • Frontal Lobe
  • Magnetic Resonance Imaging


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