Prefrontal and temporal gray matter density decreases in opiate dependence

In Kyoon Lyoo, Mark H. Pollack, Marisa M. Silveri, Heup Ahn Kyung, Claudia I. Diaz, Jaeuk Hwang, Ju Kim Seog, Deborah A. Yurgelun-Todd, Marc J. Kaufman, Perry F. Renshaw

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


Rationale: There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects. Objectives: The objective of the current study is to explore gray matter density in opiate-dependent subjects. Methods: Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM. Results: Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28). Conclusions: This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
Issue number2
StatePublished - Feb 2006

Bibliographical note

Funding Information:
Acknowledgements This study was supported by grants NIDA DA11231 (M.P.H.), DA017324 (M.J.K.), DA09448, DA15116 (P.F. R.), and NARSAD Young Investigator and the Harvard-MIT Clinical Investigator Training Program (I.K.L.).


  • Abuse
  • Brain imaging
  • Opiate
  • Voxel-based morphometry


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