Predictors of mortality in Middle East respiratory syndrome (MERS)

Ki Ho Hong, Jae Phil Choi, Seon Hui Hong, Jeewon Lee, Ji Soo Kwon, Sun Mi Kim, Se Yoon Park, Ji Young Rhee, Baek Nam Kim, Hee Jung Choi, Eui Cheol Shin, Hyunjoo Pai, Su Hyung Park, Sung Han Kim

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.

Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalThorax
Volume73
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • infection control
  • respiratory infection
  • viral infection

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