Predictors of mortality in Middle East respiratory syndrome (MERS)

Ki Ho Hong; Jae Phil Choi; Seon Hui Hong; Jeewon Lee; Ji Soo Kwon; Sun Mi Kim; Se Yoon Park; Ji Young Rhee; Baek Nam Kim; Hee Jung Choi; Eui Cheol Shin; Hyunjoo Pai; Su Hyung Park; Sung Han Kim

doi:10.1136/thoraxjnl-2016-209313

Predictors of mortality in Middle East respiratory syndrome (MERS)

Ki Ho Hong, Jae Phil Choi, Seon Hui Hong, Jeewon Lee, Ji Soo Kwon, Sun Mi Kim, Se Yoon Park, Ji Young Rhee, Baek Nam Kim, Hee Jung Choi, Eui Cheol Shin, Hyunjoo Pai, Su Hyung Park, Sung Han Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.

Original language	English
Pages (from-to)	286-289
Number of pages	4
Journal	Thorax
Volume	73
Issue number	3
DOIs	https://doi.org/10.1136/thoraxjnl-2016-209313
State	Published - Mar 2018

Keywords

infection control
respiratory infection
viral infection

Access to Document

10.1136/thoraxjnl-2016-209313

Cite this

@article{986586966b2c4e79bb456dd76b700186,

title = "Predictors of mortality in Middle East respiratory syndrome (MERS)",

abstract = "We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.",

keywords = "infection control, respiratory infection, viral infection",

author = "Hong, {Ki Ho} and Choi, {Jae Phil} and Hong, {Seon Hui} and Jeewon Lee and Kwon, {Ji Soo} and Kim, {Sun Mi} and Park, {Se Yoon} and Rhee, {Ji Young} and Kim, {Baek Nam} and Choi, {Hee Jung} and Shin, {Eui Cheol} and Hyunjoo Pai and Park, {Su Hyung} and Kim, {Sung Han}",

note = "Funding Information: Funding This study was supported by grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI15C2774, HI15C2859 and HI15C2888), from the National Research Foundation, funded by the Ministry of Science, ICT and Future Planning, Republic of Korea (NRF-2015R1A4A1042416), and from the Asan Institute for Life Sciences (Grant No. 2016-462). It was also supported by the Korean Society for Chemotherapy. Publisher Copyright: {\textcopyright} 2017 author(s).",

year = "2018",

month = mar,

doi = "10.1136/thoraxjnl-2016-209313",

language = "English",

volume = "73",

pages = "286--289",

journal = "Thorax",

issn = "0040-6376",

publisher = "BMJ Publishing Group",

number = "3",

}

TY - JOUR

T1 - Predictors of mortality in Middle East respiratory syndrome (MERS)

AU - Hong, Ki Ho

AU - Choi, Jae Phil

AU - Hong, Seon Hui

AU - Lee, Jeewon

AU - Kwon, Ji Soo

AU - Kim, Sun Mi

AU - Park, Se Yoon

AU - Rhee, Ji Young

AU - Kim, Baek Nam

AU - Choi, Hee Jung

AU - Shin, Eui Cheol

AU - Pai, Hyunjoo

AU - Park, Su Hyung

AU - Kim, Sung Han

N1 - Funding Information: Funding This study was supported by grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI15C2774, HI15C2859 and HI15C2888), from the National Research Foundation, funded by the Ministry of Science, ICT and Future Planning, Republic of Korea (NRF-2015R1A4A1042416), and from the Asan Institute for Life Sciences (Grant No. 2016-462). It was also supported by the Korean Society for Chemotherapy. Publisher Copyright: © 2017 author(s).

PY - 2018/3

Y1 - 2018/3

N2 - We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.

AB - We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.

KW - infection control

KW - respiratory infection

KW - viral infection

UR - http://www.scopus.com/inward/record.url?scp=85040688362&partnerID=8YFLogxK

U2 - 10.1136/thoraxjnl-2016-209313

DO - 10.1136/thoraxjnl-2016-209313

M3 - Article

C2 - 28724637

AN - SCOPUS:85040688362

SN - 0040-6376

VL - 73

SP - 286

EP - 289

JO - Thorax

JF - Thorax

IS - 3

ER -

Predictors of mortality in Middle East respiratory syndrome (MERS)

Abstract

Keywords

Access to Document

Fingerprint

Cite this