Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation

M. H. Lee; J. H. Jang; H. J. Min; H. I. Jang; J. H. Nah; C. J. Lyu; K. S. Han; J. H. Won; Y. H. Lee; S. Y. Chong; Y. C. Mun; W. S. Lee; S. J. Kim; I. Kim

doi:10.1038/bmt.2016.260

Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation

M. H. Lee, J. H. Jang, H. J. Min, H. I. Jang, J. H. Nah, C. J. Lyu, K. S. Han, J. H. Won, Y. H. Lee, S. Y. Chong, Y. C. Mun, W. S. Lee, S. J. Kim, I. Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.

Original language	English
Pages (from-to)	258-263
Number of pages	6
Journal	Bone Marrow Transplantation
Volume	52
Issue number	2
DOIs	https://doi.org/10.1038/bmt.2016.260
State	Published - 1 Feb 2017

Bibliographical note

Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Access to Document

10.1038/bmt.2016.260

Cite this

Lee, M. H., Jang, J. H., Min, H. J., Jang, H. I., Nah, J. H., Lyu, C. J., Han, K. S., Won, J. H., Lee, Y. H., Chong, S. Y., Mun, Y. C., Lee, W. S., Kim, S. J., & Kim, I. (2017). Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation. Bone Marrow Transplantation, 52(2), 258-263. https://doi.org/10.1038/bmt.2016.260

@article{79bd1127ad084b80b3a42d4f07158205,

title = "Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation",

abstract = "We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.",

author = "Lee, {M. H.} and Jang, {J. H.} and Min, {H. J.} and Jang, {H. I.} and Nah, {J. H.} and Lyu, {C. J.} and Han, {K. S.} and Won, {J. H.} and Lee, {Y. H.} and Chong, {S. Y.} and Mun, {Y. C.} and Lee, {W. S.} and Kim, {S. J.} and I. Kim",

year = "2017",

month = feb,

day = "1",

doi = "10.1038/bmt.2016.260",

language = "English",

volume = "52",

pages = "258--263",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "2",

}

Lee, MH, Jang, JH, Min, HJ, Jang, HI, Nah, JH, Lyu, CJ, Han, KS, Won, JH, Lee, YH, Chong, SY, Mun, YC, Lee, WS, Kim, SJ & Kim, I 2017, 'Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation', Bone Marrow Transplantation, vol. 52, no. 2, pp. 258-263. https://doi.org/10.1038/bmt.2016.260

TY - JOUR

T1 - Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation

AU - Lee, M. H.

AU - Jang, J. H.

AU - Min, H. J.

AU - Jang, H. I.

AU - Nah, J. H.

AU - Lyu, C. J.

AU - Han, K. S.

AU - Won, J. H.

AU - Lee, Y. H.

AU - Chong, S. Y.

AU - Mun, Y. C.

AU - Lee, W. S.

AU - Kim, S. J.

AU - Kim, I.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.

AB - We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.

UR - http://www.scopus.com/inward/record.url?scp=84994635693&partnerID=8YFLogxK

U2 - 10.1038/bmt.2016.260

DO - 10.1038/bmt.2016.260

M3 - Article

C2 - 27819689

AN - SCOPUS:84994635693

SN - 0268-3369

VL - 52

SP - 258

EP - 263

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 2

ER -

Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this