Abstract
Unlike bacteria, which generally consist of a single intracellular compartment surrounded by a plasma membrane, a eukaryotic cell is elaborately subdivided into functionally distinct, membrane-enclosed intracellular compartments that are composed of the nucleus, mitochondria, and chloroplast. Although transmembrane spanning region and topology prediction tools are available, such software cannot distinguish plasma membrane from intracellular membrane. Moreover, the presence of signal peptide, which has information of intracellular targeting, complicates the transmembrane topology prediction because the hydrophobic composite of signal peptide is considered to be a putative transmembrane region. By immediately detecting a signal peptide and transmembrane topology in a query sequence, we can discriminate plasma membrane spanning proteins from intracellular membrane spanning proteins. Moreover, the prediction performance significantly increases when signal peptide is contained in queries. Transmembrane region prediction algorithm based on the Hidden Markov Model and ER signal peptide detection architecture for neural networks has been used for the actual implementation of the software.
Original language | English |
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Title of host publication | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
Editors | Mircea Gh. Negoita, Robert J. Howlett, Lakhmi C. Jain |
Publisher | Springer Verlag |
Pages | 270-277 |
Number of pages | 8 |
ISBN (Print) | 9783540232056 |
DOIs | |
State | Published - 2004 |
Event | 8th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, KES 2004 - Wellington, New Zealand Duration: 20 Sep 2004 → 25 Sep 2004 |
Publication series
Name | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
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Volume | 3215 |
ISSN (Print) | 0302-9743 |
ISSN (Electronic) | 1611-3349 |
Conference
Conference | 8th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, KES 2004 |
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Country/Territory | New Zealand |
City | Wellington |
Period | 20/09/04 → 25/09/04 |
Bibliographical note
Publisher Copyright:© Springer-Verlag Berlin Heidelberg 2004.