Predicting peri-device leakage of left atrial appendage device closure using novel three-dimensional geometric CT analysis

Hyemoon Chung, Byunghwan Jeon, Hyuk Jae Chang, Dongjin Han, Hackjoon Shim, In Jeong Cho, Chi Young Shim, Geu Ru Hong, Jung Sun Kim, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: After left atrial appendage (LAA) device closure, peri-device leakage into the LAA persists due to incomplete occlusion. We hypothesized that pre-procedural three-dimensional (3D) geometric analysis of the interatrial septum (IAS) and LAA orifice can predict this leakage. We investigated the predictive parameters of LAA device closure obtained from baseline cardiac computerized tomography (CT) using a novel 3D analysis system. Methods: We conducted a retrospective study of 22 patients who underwent LAA device closure. We defined peri-device leakage as the presence of a Doppler signal inside the LAA after device deployment (group 2, n = 5) compared with patients without peri-device leakage (group 1, n = 17). Conventional parameters were measured by cardiac CT. Angles θ and φ were defined between the IAS plane and the line, linking the LAA orifice center and foramen ovale. Results: Group 2 exhibited significantly better left atrial (LA) function than group 1 (p = 0.031). Pre-procedural θ was also larger in this group (41.9° vs. 52.3°, p = 0.019). The LAA cauliflower-type morphology was more common in group 2. Overall, the patients’ LA reserve significantly decreased after the procedure (21.7 mm3 vs. 17.8 mm3, p = 0.035). However, we observed no significant interval changes in pre- and post-procedural values of θ and φ in either group (all p > 0.05). Conclusion: Angles between the IAS and LAA orifice might be a novel anatomical parameter for predicting peri-device leakage after LAA device closure. In addition, 3D CT analysis of the LA and LAA orifice could be used to identify clinically favorable candidates for LAA device closure.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalJournal of Cardiovascular Ultrasound
Issue number4
StatePublished - 25 Dec 2015


  • Cardiac CT
  • Left atrial appendage
  • Occlusion
  • Peri-device leakage


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