Predicting oxygen uptake for men with moderate to severe chronic obstructive pulmonary disease

Changhwan Kim; Bum Park Yong; Kyung Mo Eun; Hee Choi Eun; Seung Nam Hee; Sung Soon Lee; Won Yoo Young; Jun Yang Yun; Wha Moon Joung; Soon Kim Dong; Yi Lee Hyang; Soo Jin Young; Young Lee Hye; Mi Chun Eun

doi:10.4046/trd.2008.64.6.433

Predicting oxygen uptake for men with moderate to severe chronic obstructive pulmonary disease

Changhwan Kim, Bum Park Yong, Kyung Mo Eun, Hee Choi Eun, Seung Nam Hee, Sung Soon Lee, Won Yoo Young, Jun Yang Yun, Wha Moon Joung, Soon Kim Dong, Yi Lee Hyang, Soo Jin Young, Young Lee Hye, Mi Chun Eun

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Measurement of the maximum oxygen uptake in patients with chronic obstructive pulmonary disease (COPD) has been used to determine the intensity of exercise and to estimate the patient's response to treatment during pulmonary rehabilitation. However, cardiopulmonary exercise testing is not widely available in Korea. The 6-minute walk test (6MWT) is a simple method of measuring the exercise capacity of a patient. It also provides high reliability data and it reflects the fluctuation in one' s exercise capacity relatively well with using the standardized protocol. The prime objective of the present study is to develop a regression equation for estimating the peak oxygen uptake (VO₂) for men with moderate to very severe COPD from the results of a 6MWT. Methods: A total of 33 male patients with moderate to very severe COPD agreed to participate in this study. Pulmonary function testing, cardiopulmonary exercise testing and a 6MWT were performed on their first visits. The index of work (6M_work, 6-minute walk distance [6MWD]xbody weight) was calculated for each patient. Those variables that were closely related to the peak VO₂ were identified through correlation analysis. With including such variables, the equation to predict the peak VO₂ was generated by the multiple linear regression method. Results: The peak VO₂ averaged 1,015±392 ml/min, and the mean 6MWD was 516±195 meters. The 6M_work (r=.597) was better correlated to the peak VO₂ than the 6MWD (r=.415). The other variables highly correlated with the peak VO₂ were the FEV₁ (r=.742), DLco (r=.734) and FVC (r=.679). The derived prediction equation was VO₂ (ml/min)=(274.306xFEV₁)+(36.242xDLco)+(0.007x6M_work)-84. 867. Conclusion: Under the circumstances when measurement of the peak VO ₂ is not possible, we consider the 6MWT to be a simple alternative to measuring the peak VO₂. Of course, it is necessary to perform a trial on much larger scale to validate our prediction equation.

Original language	English
Pages (from-to)	433-438
Number of pages	6
Journal	Tuberculosis and Respiratory Diseases
Volume	64
Issue number	6
DOIs	https://doi.org/10.4046/trd.2008.64.6.433
State	Published - Jun 2008

Keywords

6-minute walk test
COPD
Peak oxygen uptake

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10.4046/trd.2008.64.6.433

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Kim, C., Yong, B. P., Eun, K. M., Eun, H. C., Hee, S. N., Lee, S. S., Young, W. Y., Yun, J. Y., Joung, W. M., Dong, S. K., Hyang, Y. L., Young, S. J., Hye, Y. L., & Eun, M. C. (2008). Predicting oxygen uptake for men with moderate to severe chronic obstructive pulmonary disease. Tuberculosis and Respiratory Diseases, 64(6), 433-438. https://doi.org/10.4046/trd.2008.64.6.433

@article{96cac0012b834d31b5f188c8f61f50c1,

title = "Predicting oxygen uptake for men with moderate to severe chronic obstructive pulmonary disease",

abstract = "Background: Measurement of the maximum oxygen uptake in patients with chronic obstructive pulmonary disease (COPD) has been used to determine the intensity of exercise and to estimate the patient's response to treatment during pulmonary rehabilitation. However, cardiopulmonary exercise testing is not widely available in Korea. The 6-minute walk test (6MWT) is a simple method of measuring the exercise capacity of a patient. It also provides high reliability data and it reflects the fluctuation in one' s exercise capacity relatively well with using the standardized protocol. The prime objective of the present study is to develop a regression equation for estimating the peak oxygen uptake (VO2) for men with moderate to very severe COPD from the results of a 6MWT. Methods: A total of 33 male patients with moderate to very severe COPD agreed to participate in this study. Pulmonary function testing, cardiopulmonary exercise testing and a 6MWT were performed on their first visits. The index of work (6Mwork, 6-minute walk distance [6MWD]xbody weight) was calculated for each patient. Those variables that were closely related to the peak VO2 were identified through correlation analysis. With including such variables, the equation to predict the peak VO2 was generated by the multiple linear regression method. Results: The peak VO2 averaged 1,015±392 ml/min, and the mean 6MWD was 516±195 meters. The 6Mwork (r=.597) was better correlated to the peak VO2 than the 6MWD (r=.415). The other variables highly correlated with the peak VO2 were the FEV1 (r=.742), DLco (r=.734) and FVC (r=.679). The derived prediction equation was VO2 (ml/min)=(274.306xFEV1)+(36.242xDLco)+(0.007x6Mwork)-84. 867. Conclusion: Under the circumstances when measurement of the peak VO 2 is not possible, we consider the 6MWT to be a simple alternative to measuring the peak VO2. Of course, it is necessary to perform a trial on much larger scale to validate our prediction equation.",

keywords = "6-minute walk test, COPD, Peak oxygen uptake",

author = "Changhwan Kim and Yong, {Bum Park} and Eun, {Kyung Mo} and Eun, {Hee Choi} and Hee, {Seung Nam} and Lee, {Sung Soon} and Young, {Won Yoo} and Yun, {Jun Yang} and Joung, {Wha Moon} and Dong, {Soon Kim} and Hyang, {Yi Lee} and Young, {Soo Jin} and Hye, {Young Lee} and Eun, {Mi Chun}",

year = "2008",

month = jun,

doi = "10.4046/trd.2008.64.6.433",

language = "English",

volume = "64",

pages = "433--438",

journal = "Tuberculosis and Respiratory Diseases",

issn = "1738-3536",

publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",

number = "6",

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TY - JOUR

T1 - Predicting oxygen uptake for men with moderate to severe chronic obstructive pulmonary disease

AU - Kim, Changhwan

AU - Yong, Bum Park

AU - Eun, Kyung Mo

AU - Eun, Hee Choi

AU - Hee, Seung Nam

AU - Lee, Sung Soon

AU - Young, Won Yoo

AU - Yun, Jun Yang

AU - Joung, Wha Moon

AU - Dong, Soon Kim

AU - Hyang, Yi Lee

AU - Young, Soo Jin

AU - Hye, Young Lee

AU - Eun, Mi Chun

PY - 2008/6

Y1 - 2008/6

N2 - Background: Measurement of the maximum oxygen uptake in patients with chronic obstructive pulmonary disease (COPD) has been used to determine the intensity of exercise and to estimate the patient's response to treatment during pulmonary rehabilitation. However, cardiopulmonary exercise testing is not widely available in Korea. The 6-minute walk test (6MWT) is a simple method of measuring the exercise capacity of a patient. It also provides high reliability data and it reflects the fluctuation in one' s exercise capacity relatively well with using the standardized protocol. The prime objective of the present study is to develop a regression equation for estimating the peak oxygen uptake (VO2) for men with moderate to very severe COPD from the results of a 6MWT. Methods: A total of 33 male patients with moderate to very severe COPD agreed to participate in this study. Pulmonary function testing, cardiopulmonary exercise testing and a 6MWT were performed on their first visits. The index of work (6Mwork, 6-minute walk distance [6MWD]xbody weight) was calculated for each patient. Those variables that were closely related to the peak VO2 were identified through correlation analysis. With including such variables, the equation to predict the peak VO2 was generated by the multiple linear regression method. Results: The peak VO2 averaged 1,015±392 ml/min, and the mean 6MWD was 516±195 meters. The 6Mwork (r=.597) was better correlated to the peak VO2 than the 6MWD (r=.415). The other variables highly correlated with the peak VO2 were the FEV1 (r=.742), DLco (r=.734) and FVC (r=.679). The derived prediction equation was VO2 (ml/min)=(274.306xFEV1)+(36.242xDLco)+(0.007x6Mwork)-84. 867. Conclusion: Under the circumstances when measurement of the peak VO 2 is not possible, we consider the 6MWT to be a simple alternative to measuring the peak VO2. Of course, it is necessary to perform a trial on much larger scale to validate our prediction equation.

AB - Background: Measurement of the maximum oxygen uptake in patients with chronic obstructive pulmonary disease (COPD) has been used to determine the intensity of exercise and to estimate the patient's response to treatment during pulmonary rehabilitation. However, cardiopulmonary exercise testing is not widely available in Korea. The 6-minute walk test (6MWT) is a simple method of measuring the exercise capacity of a patient. It also provides high reliability data and it reflects the fluctuation in one' s exercise capacity relatively well with using the standardized protocol. The prime objective of the present study is to develop a regression equation for estimating the peak oxygen uptake (VO2) for men with moderate to very severe COPD from the results of a 6MWT. Methods: A total of 33 male patients with moderate to very severe COPD agreed to participate in this study. Pulmonary function testing, cardiopulmonary exercise testing and a 6MWT were performed on their first visits. The index of work (6Mwork, 6-minute walk distance [6MWD]xbody weight) was calculated for each patient. Those variables that were closely related to the peak VO2 were identified through correlation analysis. With including such variables, the equation to predict the peak VO2 was generated by the multiple linear regression method. Results: The peak VO2 averaged 1,015±392 ml/min, and the mean 6MWD was 516±195 meters. The 6Mwork (r=.597) was better correlated to the peak VO2 than the 6MWD (r=.415). The other variables highly correlated with the peak VO2 were the FEV1 (r=.742), DLco (r=.734) and FVC (r=.679). The derived prediction equation was VO2 (ml/min)=(274.306xFEV1)+(36.242xDLco)+(0.007x6Mwork)-84. 867. Conclusion: Under the circumstances when measurement of the peak VO 2 is not possible, we consider the 6MWT to be a simple alternative to measuring the peak VO2. Of course, it is necessary to perform a trial on much larger scale to validate our prediction equation.

KW - 6-minute walk test

KW - COPD

KW - Peak oxygen uptake

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U2 - 10.4046/trd.2008.64.6.433

DO - 10.4046/trd.2008.64.6.433

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AN - SCOPUS:47149088681

SN - 1738-3536

VL - 64

SP - 433

EP - 438

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

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ER -

Predicting oxygen uptake for men with moderate to severe chronic obstructive pulmonary disease

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