@article{c3e49e0b11ad43de9941d216f376caba,
title = "Predicting cognitive stage transition using p-tau181, Centiloid, and other measures",
abstract = "BACKGROUND: A combination of plasma phospho-tau (p-tau), amyloid beta (Aβ)-positron emission tomography (PET), brain magnetic resonance imaging, cognitive function tests, and other biomarkers might predict future cognitive decline. This study aimed to investigate the efficacy of combining these biomarkers in predicting future cognitive stage transitions within 3 years. METHODS: Among the participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE-V) study, 49 mild cognitive impairment (MCI) and 113 cognitively unimpaired (CU) participants with Aβ-PET and brain imaging data were analyzed. RESULTS: Older age, increased plasma p-tau181, Aβ-PET positivity, and decreased semantic fluency were independently associated with cognitive stage transitions. Combining age, p-tau181, the Centiloid scale, semantic fluency, and hippocampal volume produced high predictive value in predicting future cognitive stage transition (area under the curve = 0.879). CONCLUSIONS: Plasma p-tau181 and Centiloid scale alone or in combination with other biomarkers, might predict future cognitive stage transition in non-dementia patients. Highlights: -Plasma p-tau181 and Centiloid scale might predict future cognitive stage transition. -Combining them or adding other biomarkers increased the predictive value. -Factors that independently associated with cognitive stage transition were demonstrated.",
keywords = "Alzheimer's disease, Centiloid, cognitive stage, p-tau, prognosis",
author = "Kwon, {Hyuk Sung} and Kim, {Ji Young} and Koh, {Seong Ho} and Choi, {Seong Hye} and Lee, {Eun Hye} and Jeong, {Jee Hyang} and Jang, {Jae Won} and Park, {Kyung Won} and Kim, {Eun Joo} and Hong, {Jin Yong} and Yoon, {Soo Jin} and Bora Yoon and Park, {Hyun Hee} and Han, {Myung Hoon}",
note = "Funding Information: This study was supported by grants from the National Research Council of Science & Technology (NST) Aging Convergence Research Center (CRC22011‐600), the Institute of Information & Communications Technology Planning & Evaluation (IITP) (No. 2022‐0‐00448), the Basic Science Research Program through the National Research Foundation of Korea (NRF) (NRF‐2022R1F1A1063739, NRF‐2020M3E5D2A01084721, NRF‐2018M3A9F1023697, and 2022R1F1A1072546) funded by the Ministry of Science and ICT, Republic of Korea, the research fund of Hanyang University (HY‐202200000003470) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and Korea Dementia Research Center (KDRC) funded by the Ministry of Health & Welfare and Ministry of Science and ICT, Republic of Korea (HI20C0253, HU21C0113, HU21C0016, and HU21C0007). Bredis Healthcare Inc. (Seoul, South Korea; http://www.bredis.co.kr) helped us with the experiments for the immunoassays. We would like to thank Bredis Healthcare Inc. under the supervision of Dr. H. Hwang. Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
year = "2023",
doi = "10.1002/alz.13054",
language = "English",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "John Wiley & Sons Inc.",
}
