Precursor Heterogeneity Driven Mo-Te Nanoparticle Structural Diversification for Cancer Photo-Theranostics

Gyeonghye Yim, Seounghun Kang, Se Youl Chae, Euisuk Chung, Tai Kyong Song, Ji Hun Park, Changhan Yoon, Dal Hee Min, Hongje Jang

Research output: Contribution to journalArticlepeer-review


Chemical reactions between homogeneous precursors are typically used to synthesize monodisperse nanoparticles with well-controlled size and morphology. It is difficult to predict the evolved nanostructures when using two heterogeneous precursors. In this study, three types of Mo-Te nanoparticles shaped like leaves, spindles, and rice grains (denoted respectively as nanoleaf, nanospindle, and nanorice) were obtained from dextrose-mediated proton-coupled electron transfer reaction between the solid polyoxomolybdate (POM) and the ionic tellurite anion as precursors. All produced nanoparticles had excellent optical absorption in the ultraviolet(UV)-visible(Vis)-near-infrared(NIR) regions, with only slight deviations among them. After confirming nanoparticles' photothermal conversion and photocatalytic activity at multiple wavelengths, the Mo-Te nanorice was tested as a potential agent for cancer treatment due to its minimum toxicity, excellent colloidal stability, and intrinsic anticancer effect. Excellent treatment efficacy and clearance were confirmed in vitro and in vivo. Due to their photoacoustic imaging capability, the injection of pristine nanoparticles could also realize phototheranostics without using additional drugs, probes, or photosensitizers.

Original languageEnglish
Pages (from-to)9987-10000
Number of pages14
JournalACS Applied Materials and Interfaces
Issue number8
StatePublished - 2 Mar 2022

Bibliographical note

Funding Information:
This research was supported by the National Convergence Research of Scientific Challenges (NRF-2020M3F7A1094299) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT. This work was supported by National Research Foundation of Korea (NRF) funded by Korean government (NRF-2019R1C1C1002305, NRF-2019R1A2C1089813, and 2021R1A6A1A03038785). This work was supported by the Basic Science Research Program (2016R1E1A1A01941202 and 2016R1A4A1010796) through the NRF.

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.


  • cancer therapy
  • molybdenum
  • photoacoustic imaging
  • phototherapy
  • tellurium


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