Pre-wetting process with helium atmospheric pressure glow discharge for three-dimensional porous scaffold

Inho Han; Barbora Vagaska; Dae Hyung Lee; Bong Joo Park; Seung Woo Shin; Jeong Koo Kim; Seung Jin Lee; Jong Chul Park

doi:10.1007/s13233-011-0701-7

Pre-wetting process with helium atmospheric pressure glow discharge for three-dimensional porous scaffold

Inho Han, Barbora Vagaska, Dae Hyung Lee, Bong Joo Park, Seung Woo Shin, Jeong Koo Kim, Seung Jin Lee, Jong Chul Park

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Recently, three-dimensional polymer scaffolds were developed for tissue regeneration. Conventional pre-wetting processes require a lengthy processing time and have residue problems. In this study, a helium atmospheric pressure glow discharge (He-APGD) was employed as a pre-wetting process for porous poly-(L-lactide-co-ε-caprolactone) (PLCL) scaffold. The three minutes treated PLCL scaffold absorbed the culture media and contained grafted hydroxyl, carbonyl, and carboxyl groups. Moreover, it did not show cytotoxicity, did not require residual rinsing steps and showed a homogeneous cell distribution. The He-APGD treatment has a short processing time and promotes a homogenous cell distribution. Therefore, this pre-wetting process is expected to find many applications in the future.

Original language	English
Pages (from-to)	711-715
Number of pages	5
Journal	Macromolecular Research
Volume	19
Issue number	7
DOIs	https://doi.org/10.1007/s13233-011-0701-7
State	Published - Jul 2011

Keywords

biodegradable polymer scaffold
plasma
porous polymer scaffold
surface modification

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title = "Pre-wetting process with helium atmospheric pressure glow discharge for three-dimensional porous scaffold",

abstract = "Recently, three-dimensional polymer scaffolds were developed for tissue regeneration. Conventional pre-wetting processes require a lengthy processing time and have residue problems. In this study, a helium atmospheric pressure glow discharge (He-APGD) was employed as a pre-wetting process for porous poly-(L-lactide-co-ε-caprolactone) (PLCL) scaffold. The three minutes treated PLCL scaffold absorbed the culture media and contained grafted hydroxyl, carbonyl, and carboxyl groups. Moreover, it did not show cytotoxicity, did not require residual rinsing steps and showed a homogeneous cell distribution. The He-APGD treatment has a short processing time and promotes a homogenous cell distribution. Therefore, this pre-wetting process is expected to find many applications in the future.",

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AU - Han, Inho

AU - Vagaska, Barbora

AU - Lee, Dae Hyung

AU - Park, Bong Joo

AU - Shin, Seung Woo

AU - Kim, Jeong Koo

AU - Lee, Seung Jin

AU - Park, Jong Chul

PY - 2011/7

Y1 - 2011/7

N2 - Recently, three-dimensional polymer scaffolds were developed for tissue regeneration. Conventional pre-wetting processes require a lengthy processing time and have residue problems. In this study, a helium atmospheric pressure glow discharge (He-APGD) was employed as a pre-wetting process for porous poly-(L-lactide-co-ε-caprolactone) (PLCL) scaffold. The three minutes treated PLCL scaffold absorbed the culture media and contained grafted hydroxyl, carbonyl, and carboxyl groups. Moreover, it did not show cytotoxicity, did not require residual rinsing steps and showed a homogeneous cell distribution. The He-APGD treatment has a short processing time and promotes a homogenous cell distribution. Therefore, this pre-wetting process is expected to find many applications in the future.

AB - Recently, three-dimensional polymer scaffolds were developed for tissue regeneration. Conventional pre-wetting processes require a lengthy processing time and have residue problems. In this study, a helium atmospheric pressure glow discharge (He-APGD) was employed as a pre-wetting process for porous poly-(L-lactide-co-ε-caprolactone) (PLCL) scaffold. The three minutes treated PLCL scaffold absorbed the culture media and contained grafted hydroxyl, carbonyl, and carboxyl groups. Moreover, it did not show cytotoxicity, did not require residual rinsing steps and showed a homogeneous cell distribution. The He-APGD treatment has a short processing time and promotes a homogenous cell distribution. Therefore, this pre-wetting process is expected to find many applications in the future.

KW - biodegradable polymer scaffold

KW - plasma

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KW - surface modification

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Pre-wetting process with helium atmospheric pressure glow discharge for three-dimensional porous scaffold

Abstract

Keywords

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