Potentially bioactive two new natural sesquiterpenoids from the rhizomes of Zingiber zerumbet

Sik Jang Dae, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Repeated chromatography of the n-hexane-soluble fraction of the MeOH extract of the rhizomes of Zingiber zerumbet led to the isolation of two isomers of 6-methoxy-2E,9E-humuladien-8-one (1 and 2) and stigmast-4-en-3-one. The structures of 1 and 2 were determined by spectroscopic methods including 1D and 2D-NMR elucidated by analysis of spectroscopic data as well as by comparison with published values. This is the first report on the isolation of compounds 1 and 2 from the nature. Stigmast-4-en-3-one was first isolated from this plant.

Original languageEnglish
Pages (from-to)294-296
Number of pages3
JournalArchives of Pharmacal Research
Issue number3
StatePublished - 31 Mar 2005

Bibliographical note

Funding Information:
This study was supported by the Korea Science and Engineering Foundation for the National R&D Program for Enhancing R&D Infrastructure of Womens University \[R06-2002-011-01002-0(2002)\]. We are grateful to Prof. Tri Windono and Dr. Gwang-Ho Jeohn at Surabaya University, Surabaya, Indonesia for plant collection.


  • 6-Methoxy-2E,9E- humuladien-8-one
  • Sesquiterpenoids
  • Stigmast-4-en-3-one
  • Zingiber zerumbet
  • Zingiberaceae


Dive into the research topics of 'Potentially bioactive two new natural sesquiterpenoids from the rhizomes of Zingiber zerumbet'. Together they form a unique fingerprint.

Cite this