Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair

Eunhyun Choi; Jiyun Lee; Seahyoung Lee; Byeong Wook Song; Hyang Hee Seo; Min Ji Cha; Soyeon Lim; Chulho Lee; Suk Won Song; Gyoonhee Han; Ki Chul Hwang

doi:10.1016/j.bmcl.2016.08.069

Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair

Eunhyun Choi, Jiyun Lee, Seahyoung Lee, Byeong Wook Song, Hyang Hee Seo, Min Ji Cha, Soyeon Lim, Chulho Lee, Suk Won Song, Gyoonhee Han, Ki Chul Hwang

Department of Thoraxic and Cardiovascular Surgery

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The restoration of damaged articular cartilage is a long-pursued goal in regenerative medicine. Chondrocyte-specific differentiation of mesenchymal stem cells (MSCs) may be an effective means of repairing damaged cartilage. We identified small molecule 6 with sulfonamide as an agent that promotes specific chondrogenic differentiation of human adipose-derived MSCs (hASCs). Unlike other chondrogenic differentiation media composed of various defined components, simply adding compound 6 into culture medium was sufficient to induce chondrogenesis in this study. In an animal osteoarthritis model, both the small molecule 6 and the 6-treated hASCs exhibited enhanced recovery of injured articular cartilage. This work provides new insight into MSC differentiation induced by small molecules and potential new therapeutic approaches for articular cartilage injury.

Original language	English
Pages (from-to)	5098-5102
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2016.08.069
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016

Keywords

Chondrogenesis
Mesenchymal stem cells
Osteoarthritis
Regenerative medicine
Sulfonamide

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10.1016/j.bmcl.2016.08.069

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title = "Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair",

abstract = "The restoration of damaged articular cartilage is a long-pursued goal in regenerative medicine. Chondrocyte-specific differentiation of mesenchymal stem cells (MSCs) may be an effective means of repairing damaged cartilage. We identified small molecule 6 with sulfonamide as an agent that promotes specific chondrogenic differentiation of human adipose-derived MSCs (hASCs). Unlike other chondrogenic differentiation media composed of various defined components, simply adding compound 6 into culture medium was sufficient to induce chondrogenesis in this study. In an animal osteoarthritis model, both the small molecule 6 and the 6-treated hASCs exhibited enhanced recovery of injured articular cartilage. This work provides new insight into MSC differentiation induced by small molecules and potential new therapeutic approaches for articular cartilage injury.",

keywords = "Chondrogenesis, Mesenchymal stem cells, Osteoarthritis, Regenerative medicine, Sulfonamide",

author = "Eunhyun Choi and Jiyun Lee and Seahyoung Lee and Song, {Byeong Wook} and Seo, {Hyang Hee} and Cha, {Min Ji} and Soyeon Lim and Chulho Lee and Song, {Suk Won} and Gyoonhee Han and Hwang, {Ki Chul}",

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AU - Lee, Jiyun

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AU - Song, Byeong Wook

AU - Seo, Hyang Hee

AU - Cha, Min Ji

AU - Lim, Soyeon

AU - Lee, Chulho

AU - Song, Suk Won

AU - Han, Gyoonhee

AU - Hwang, Ki Chul

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AB - The restoration of damaged articular cartilage is a long-pursued goal in regenerative medicine. Chondrocyte-specific differentiation of mesenchymal stem cells (MSCs) may be an effective means of repairing damaged cartilage. We identified small molecule 6 with sulfonamide as an agent that promotes specific chondrogenic differentiation of human adipose-derived MSCs (hASCs). Unlike other chondrogenic differentiation media composed of various defined components, simply adding compound 6 into culture medium was sufficient to induce chondrogenesis in this study. In an animal osteoarthritis model, both the small molecule 6 and the 6-treated hASCs exhibited enhanced recovery of injured articular cartilage. This work provides new insight into MSC differentiation induced by small molecules and potential new therapeutic approaches for articular cartilage injury.

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KW - Mesenchymal stem cells

KW - Osteoarthritis

KW - Regenerative medicine

KW - Sulfonamide

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Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair

Abstract

Bibliographical note

Keywords

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