Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study

Sarang Kang; Jungsoo Gim; Jiwoon Lee; Tamil Iniyan Gunasekaran; Kyu Yeong Choi; Jang Jae Lee; Eun Hyun Seo; Pan Woo Ko; Ji Yeon Chung; Seong Min Choi; Young Min Lee; Jee Hyang Jeong; Kyung Won Park; Min Kyung Song; Ho Won Lee; Ki Woong Kim; Seong Hye Choi; Dong Young Lee; Sang Yun Kim; Hoowon Kim; Byeong C. Kim; Takeshi Ikeuchi; Kun Ho Lee

doi:10.3233/JAD-210145

Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study

Sarang Kang, Jungsoo Gim, Jiwoon Lee, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Jang Jae Lee, Eun Hyun Seo, Pan Woo Ko, Ji Yeon Chung, Seong Min Choi, Young Min Lee, Jee Hyang Jeong, Kyung Won Park, Min Kyung Song, Ho Won Lee, Ki Woong Kim, Seong Hye Choi, Dong Young Lee, Sang Yun Kim, Hoowon KimByeong C. Kim, Takeshi Ikeuchi, Kun Ho Lee

Department of Neurology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ϵ4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.

Original language	English
Pages (from-to)	1451-1460
Number of pages	10
Journal	Journal of Alzheimer's Disease
Volume	82
Issue number	4
DOIs	https://doi.org/10.3233/JAD-210145
State	Published - 2021

Bibliographical note

Funding Information:
The authors greatly appreciate the reviewers’ invaluable comments that helped improving the work. This research was supported by the Original Technology Research Program for Brain Science of the National Research Foundation (NRF) funded by the Korean government, MSIT (NRF-2014M3C 7A1046041 and NRF-2014M3C7A1046042); by KBRI basic research program through Korea Brain Research Institute funded by Ministry of Science and ICT (21-BR-03-05); by Healthcare AI Convergence Research & Development Program through the National IT Industry Promotion Agency of Korea (NIPA) funded by the Ministry of Science and ICT (No.1711120216); and by Japan Agency for Medical Research and Development (AMED) (JP18kk0205009 and JP21dk0207045). This study was also supported by the National Institute on Aging of the National Institutes of Health under Award Number U01AG062602. The content is solely the responsibility of the authors and does not necessarily

Publisher Copyright:
© 2021 - The authors. Published by IOS Press.

Keywords

APOE
Alzheimer's disease
genome-wide association study
late-onset Alzheimer's disease
stratified genome analysis

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10.3233/JAD-210145

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Kang, S., Gim, J., Lee, J., Gunasekaran, T. I., Choi, K. Y., Lee, J. J., Seo, E. H., Ko, P. W., Chung, J. Y., Choi, S. M., Lee, Y. M., Jeong, J. H., Park, K. W., Song, M. K., Lee, H. W., Kim, K. W., Choi, S. H., Lee, D. Y., Kim, S. Y., ... Lee, K. H. (2021). Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study. Journal of Alzheimer's Disease, 82(4), 1451-1460. https://doi.org/10.3233/JAD-210145

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title = "Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study",

abstract = "The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ϵ4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.",

keywords = "APOE, Alzheimer's disease, genome-wide association study, late-onset Alzheimer's disease, stratified genome analysis",

author = "Sarang Kang and Jungsoo Gim and Jiwoon Lee and Gunasekaran, {Tamil Iniyan} and Choi, {Kyu Yeong} and Lee, {Jang Jae} and Seo, {Eun Hyun} and Ko, {Pan Woo} and Chung, {Ji Yeon} and Choi, {Seong Min} and Lee, {Young Min} and Jeong, {Jee Hyang} and Park, {Kyung Won} and Song, {Min Kyung} and Lee, {Ho Won} and Kim, {Ki Woong} and Choi, {Seong Hye} and Lee, {Dong Young} and Kim, {Sang Yun} and Hoowon Kim and Kim, {Byeong C.} and Takeshi Ikeuchi and Lee, {Kun Ho}",

note = "Funding Information: The authors greatly appreciate the reviewers{\textquoteright} invaluable comments that helped improving the work. This research was supported by the Original Technology Research Program for Brain Science of the National Research Foundation (NRF) funded by the Korean government, MSIT (NRF-2014M3C 7A1046041 and NRF-2014M3C7A1046042); by KBRI basic research program through Korea Brain Research Institute funded by Ministry of Science and ICT (21-BR-03-05); by Healthcare AI Convergence Research & Development Program through the National IT Industry Promotion Agency of Korea (NIPA) funded by the Ministry of Science and ICT (No.1711120216); and by Japan Agency for Medical Research and Development (AMED) (JP18kk0205009 and JP21dk0207045). This study was also supported by the National Institute on Aging of the National Institutes of Health under Award Number U01AG062602. The content is solely the responsibility of the authors and does not necessarily Publisher Copyright: {\textcopyright} 2021 - The authors. Published by IOS Press.",

year = "2021",

doi = "10.3233/JAD-210145",

language = "English",

volume = "82",

pages = "1451--1460",

journal = "Journal of Alzheimer's Disease",

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publisher = "IOS Press BV",

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Kang, S, Gim, J, Lee, J, Gunasekaran, TI, Choi, KY, Lee, JJ, Seo, EH, Ko, PW, Chung, JY, Choi, SM, Lee, YM, Jeong, JH, Park, KW, Song, MK, Lee, HW, Kim, KW, Choi, SH, Lee, DY, Kim, SY, Kim, H, Kim, BC, Ikeuchi, T & Lee, KH 2021, 'Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study', Journal of Alzheimer's Disease, vol. 82, no. 4, pp. 1451-1460. https://doi.org/10.3233/JAD-210145

TY - JOUR

T1 - Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study

AU - Kang, Sarang

AU - Gim, Jungsoo

AU - Lee, Jiwoon

AU - Gunasekaran, Tamil Iniyan

AU - Choi, Kyu Yeong

AU - Lee, Jang Jae

AU - Seo, Eun Hyun

AU - Ko, Pan Woo

AU - Chung, Ji Yeon

AU - Choi, Seong Min

AU - Lee, Young Min

AU - Jeong, Jee Hyang

AU - Park, Kyung Won

AU - Song, Min Kyung

AU - Lee, Ho Won

AU - Kim, Ki Woong

AU - Choi, Seong Hye

AU - Lee, Dong Young

AU - Kim, Sang Yun

AU - Kim, Hoowon

AU - Kim, Byeong C.

AU - Ikeuchi, Takeshi

AU - Lee, Kun Ho

N1 - Funding Information: The authors greatly appreciate the reviewers’ invaluable comments that helped improving the work. This research was supported by the Original Technology Research Program for Brain Science of the National Research Foundation (NRF) funded by the Korean government, MSIT (NRF-2014M3C 7A1046041 and NRF-2014M3C7A1046042); by KBRI basic research program through Korea Brain Research Institute funded by Ministry of Science and ICT (21-BR-03-05); by Healthcare AI Convergence Research & Development Program through the National IT Industry Promotion Agency of Korea (NIPA) funded by the Ministry of Science and ICT (No.1711120216); and by Japan Agency for Medical Research and Development (AMED) (JP18kk0205009 and JP21dk0207045). This study was also supported by the National Institute on Aging of the National Institutes of Health under Award Number U01AG062602. The content is solely the responsibility of the authors and does not necessarily Publisher Copyright: © 2021 - The authors. Published by IOS Press.

PY - 2021

Y1 - 2021

N2 - The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ϵ4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.

AB - The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ϵ4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.

KW - APOE

KW - Alzheimer's disease

KW - genome-wide association study

KW - late-onset Alzheimer's disease

KW - stratified genome analysis

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U2 - 10.3233/JAD-210145

DO - 10.3233/JAD-210145

M3 - Article

C2 - 34151794

AN - SCOPUS:85113335313

SN - 1387-2877

VL - 82

SP - 1451

EP - 1460

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 4

ER -

Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study

Abstract

Bibliographical note

Keywords

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