The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ϵ4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.
Bibliographical noteFunding Information:
The authors greatly appreciate the reviewers’ invaluable comments that helped improving the work. This research was supported by the Original Technology Research Program for Brain Science of the National Research Foundation (NRF) funded by the Korean government, MSIT (NRF-2014M3C 7A1046041 and NRF-2014M3C7A1046042); by KBRI basic research program through Korea Brain Research Institute funded by Ministry of Science and ICT (21-BR-03-05); by Healthcare AI Convergence Research & Development Program through the National IT Industry Promotion Agency of Korea (NIPA) funded by the Ministry of Science and ICT (No.1711120216); and by Japan Agency for Medical Research and Development (AMED) (JP18kk0205009 and JP21dk0207045). This study was also supported by the National Institute on Aging of the National Institutes of Health under Award Number U01AG062602. The content is solely the responsibility of the authors and does not necessarily
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- Alzheimer's disease
- genome-wide association study
- late-onset Alzheimer's disease
- stratified genome analysis