Potential novel genes for late-onset alzheimer's disease in east-asian descent identified by APOE-Stratified genome-wide association study

Sarang Kang, Jungsoo Gim, Jiwoon Lee, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Jang Jae Lee, Eun Hyun Seo, Pan Woo Ko, Ji Yeon Chung, Seong Min Choi, Young Min Lee, Jee Hyang Jeong, Kyung Won Park, Min Kyung Song, Ho Won Lee, Ki Woong Kim, Seong Hye Choi, Dong Young Lee, Sang Yun Kim, Hoowon KimByeong C. Kim, Takeshi Ikeuchi, Kun Ho Lee

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ϵ4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.

Original languageEnglish
Pages (from-to)1451-1460
Number of pages10
JournalJournal of Alzheimer's Disease
Volume82
Issue number4
DOIs
StatePublished - 2021

Keywords

  • APOE
  • Alzheimer's disease
  • genome-wide association study
  • late-onset Alzheimer's disease
  • stratified genome analysis

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