Post-translational his-cys cross-linkage formation in tyrosinase induced by copper(II)-peroxo species

Nobutaka Fujieda; Takuya Ikeda; Michiaki Murata; Sachiko Yanagisawa; Shigetoshi Aono; Kei Ohkubo; Satoshi Nagao; Takashi Ogura; Shun Hirota; Shunichi Fukuzumi; Yukihiro Nakamura; Yoji Hata; Shinobu Itoh

doi:10.1021/ja108280w

Post-translational his-cys cross-linkage formation in tyrosinase induced by copper(II)-peroxo species

Nobutaka Fujieda, Takuya Ikeda, Michiaki Murata, Sachiko Yanagisawa, Shigetoshi Aono, Kei Ohkubo, Satoshi Nagao, Takashi Ogura, Shun Hirota, Shunichi Fukuzumi, Yukihiro Nakamura, Yoji Hata, Shinobu Itoh

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Autocatalytic formation of His-Cys cross-linkage in the enzyme active site of tyrosinase from Aspergillus oryzae has been demonstrated to proceed by the treatment of apoenzyme with Cu^II under aerobic conditions, where a (μ-η²:η²-peroxo)dicopper(II) species has been suggested to be involved as a key reactive intermediate.

Original language	English
Pages (from-to)	1180-1183
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	5
DOIs	https://doi.org/10.1021/ja108280w
State	Published - 9 Feb 2011

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title = "Post-translational his-cys cross-linkage formation in tyrosinase induced by copper(II)-peroxo species",

abstract = "Autocatalytic formation of His-Cys cross-linkage in the enzyme active site of tyrosinase from Aspergillus oryzae has been demonstrated to proceed by the treatment of apoenzyme with CuII under aerobic conditions, where a (μ-η2:η2-peroxo)dicopper(II) species has been suggested to be involved as a key reactive intermediate.",

author = "Nobutaka Fujieda and Takuya Ikeda and Michiaki Murata and Sachiko Yanagisawa and Shigetoshi Aono and Kei Ohkubo and Satoshi Nagao and Takashi Ogura and Shun Hirota and Shunichi Fukuzumi and Yukihiro Nakamura and Yoji Hata and Shinobu Itoh",

year = "2011",

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doi = "10.1021/ja108280w",

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T1 - Post-translational his-cys cross-linkage formation in tyrosinase induced by copper(II)-peroxo species

AU - Fujieda, Nobutaka

AU - Ikeda, Takuya

AU - Murata, Michiaki

AU - Yanagisawa, Sachiko

AU - Aono, Shigetoshi

AU - Ohkubo, Kei

AU - Nagao, Satoshi

AU - Ogura, Takashi

AU - Hirota, Shun

AU - Fukuzumi, Shunichi

AU - Nakamura, Yukihiro

AU - Hata, Yoji

AU - Itoh, Shinobu

PY - 2011/2/9

Y1 - 2011/2/9

N2 - Autocatalytic formation of His-Cys cross-linkage in the enzyme active site of tyrosinase from Aspergillus oryzae has been demonstrated to proceed by the treatment of apoenzyme with CuII under aerobic conditions, where a (μ-η2:η2-peroxo)dicopper(II) species has been suggested to be involved as a key reactive intermediate.

AB - Autocatalytic formation of His-Cys cross-linkage in the enzyme active site of tyrosinase from Aspergillus oryzae has been demonstrated to proceed by the treatment of apoenzyme with CuII under aerobic conditions, where a (μ-η2:η2-peroxo)dicopper(II) species has been suggested to be involved as a key reactive intermediate.

UR - http://www.scopus.com/inward/record.url?scp=79551696309&partnerID=8YFLogxK

U2 - 10.1021/ja108280w

DO - 10.1021/ja108280w

M3 - Article

C2 - 21218798

AN - SCOPUS:79551696309

SN - 0002-7863

VL - 133

SP - 1180

EP - 1183

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 5

ER -

Post-translational his-cys cross-linkage formation in tyrosinase induced by copper(II)-peroxo species

Abstract

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