Abstract
Aim: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. Patients & methods: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. Results: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients. Conclusion: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK.
| Original language | English |
|---|---|
| Pages (from-to) | 1585-1594 |
| Number of pages | 10 |
| Journal | Pharmacogenomics |
| Volume | 16 |
| Issue number | 14 |
| DOIs | |
| State | Published - Sep 2015 |
Bibliographical note
Publisher Copyright:© 2015 Future Medicine Ltd.
Keywords
- GSTA1
- alloHSCT
- allogeneic hematopoietic stem cell transplantation
- busulfan
- clinical outcomes
- genetic polymorphisms
- glutathione s-transferase a1
- population pharmacokinetics