Poor long-term outcomes in stroke patients with asymptomatic coronary artery disease in heart CT

Joonsang Yoo, Dongbeom Song, Jang Hyun Baek, Kyoungsub Kim, Jinkwon Kim, Tae Jin Song, Hye Sun Lee, Donghoon Choi, Young Dae Kim, Hyo Suk Nam, Ji Hoe Heo

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background and aims Although stroke patients have a high risk of ischemic heart disease, little information is available on the risk of coronary events in stroke patients with asymptomatic coronary artery disease (CAD). We investigated the long-term vascular outcomes in stroke patients with asymptomatic CAD diagnosed with multi-detector coronary computed tomography (MDCT). Methods This study was a retrospective analysis using a prospective cohort of ischemic stroke patients. We included consecutive stroke patients without history or symptoms of CAD who underwent MDCT. We investigated the long-term risk of major adverse cardiovascular events (MACE: cardiovascular mortality, ischemic stroke, myocardial infarction, unstable angina, and urgent coronary revascularization) and composite of MACE/all-cause mortality/elective coronary revascularization. We further investigated the value of MDCT for MACE prediction. Results Among the 1893 included patients, 1349 (71.3%) patients had some degree of CAD and 654 patients (34.5%) had significant (≥50%) CAD. At follow-up (median, 4.4 years), MACE occurred in 230 patients (12.2%). Event rates of MACE increased with the increasing extent of CAD. After adjustment for age, sex, and risk factors, the hazard ratios for MACE in mild CAD, 1-VD, 2-VD, and 3-VD or left main coronary disease were 1.28 (95% confidence interval [CI]: 0.88–1.87), 1.39 (95% CI: 0.90–2.16), 2.22 (95% CI: 1.39–3.55), and 2.91 (95% CI: 1.82–4.65), respectively (no CAD as a reference). Diagnosis of asymptomatic CAD significantly improved the prediction of MACE. Conclusions Asymptomatic CAD detected on MDCT was associated with increased risks of vascular events or deaths in acute stroke patients.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
StatePublished - Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.


  • Coronary artery disease
  • Ischemic stroke
  • Major adverse cardiac event
  • Mortality
  • Multidetector computerized tomography


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