TY - JOUR
T1 - Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue
AU - Ok, Elly
AU - Do, Gyeong Min
AU - Lim, Yeni
AU - Park, Ji Eun
AU - Park, Yeo Jin
AU - Kwon, Oran
N1 - Funding Information:
We thank the company Daesang Corporation (Seoul, Korea) for its gift of pomegranate vinegar. This project was supported by Ministry of Knowledge and Economy (National Platform Technology Project B10033818).
PY - 2013
Y1 - 2013
N2 - Background: The effect of pomegranate vinegar (PV) on adiposity was investigated in high-fat diet (HF)-induced obese rats. Methods. The rats were divided into 5 groups and treated with HF with PV or acetic acid (0, 6.5 or 13% w/w) for 16 weeks. Statistical analyses were performed by the Statistical Analysis Systems package, version 9.2. Results: Compared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase (AMPK), leading to changes in mRNA expressions: increases for hormone sensitive lipase and mitochondrial uncoupling protein 2 and decreases for sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptorγ (PPARγ) in adipose tissue; increases for PPAR and carnitinepalmitoyltransferase-1a (CPT-1a) and decrease for SREBP-1c in the liver. Concomitantly, PV reduced increases of body weight (p = 0.048), fat mass (p = 0.033), hepatic triglycerides (p = 0.005), and plasma triglycerides (p = 0.001). Conclusions: These results suggest that PV attenuates adiposity through the coordinated control of AMPK, which leads to promotion of lipolysis in adipose tissue and stimulation of fatty acid oxidation in the liver.
AB - Background: The effect of pomegranate vinegar (PV) on adiposity was investigated in high-fat diet (HF)-induced obese rats. Methods. The rats were divided into 5 groups and treated with HF with PV or acetic acid (0, 6.5 or 13% w/w) for 16 weeks. Statistical analyses were performed by the Statistical Analysis Systems package, version 9.2. Results: Compared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase (AMPK), leading to changes in mRNA expressions: increases for hormone sensitive lipase and mitochondrial uncoupling protein 2 and decreases for sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptorγ (PPARγ) in adipose tissue; increases for PPAR and carnitinepalmitoyltransferase-1a (CPT-1a) and decrease for SREBP-1c in the liver. Concomitantly, PV reduced increases of body weight (p = 0.048), fat mass (p = 0.033), hepatic triglycerides (p = 0.005), and plasma triglycerides (p = 0.001). Conclusions: These results suggest that PV attenuates adiposity through the coordinated control of AMPK, which leads to promotion of lipolysis in adipose tissue and stimulation of fatty acid oxidation in the liver.
KW - AMP-activated protein kinase
KW - Fatty acid oxidation
KW - High-fat diet-induced obesity
KW - Hormone sensitive lipase
KW - Pomegranate vinegar
UR - http://www.scopus.com/inward/record.url?scp=84886735367&partnerID=8YFLogxK
U2 - 10.1186/1476-511X-12-163
DO - 10.1186/1476-511X-12-163
M3 - Article
C2 - 24180378
AN - SCOPUS:84886735367
SN - 1476-511X
VL - 12
JO - Lipids in Health and Disease
JF - Lipids in Health and Disease
IS - 1
M1 - 163
ER -