Polysaccharide-based Nanoparticles for Gene Delivery

Myung Sook Huh, Eun Jung Lee, Heebeom Koo, Ji Young Yhee, Keun Sang Oh, Sohee Son, Sojin Lee, Sun Hwa Kim, Ick Chan Kwon, Kwangmeyung Kim

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.

Original languageEnglish
Article number31
JournalTopics in current chemistry
Issue number2
StatePublished - 1 Apr 2017

Bibliographical note

Funding Information:
This study was funded by the Global Research Lab (GRL) Project (NRF-2013K1A1A2A02050115), the Global Innovative Research Center (GiRC; NRF-2012K1A1A2A01055811), and the Intramural Research Program of Korea Institute of Science and Technology (KIST).

Publisher Copyright:
© 2017, Springer International Publishing Switzerland.


  • Gene delivery
  • Nanomedicine
  • Nanoparticle
  • Nanotechnology
  • Polysaccharide
  • siRNA delivery


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