Polysaccharide-based Nanoparticles for Gene Delivery

Myung Sook Huh; Eun Jung Lee; Heebeom Koo; Ji Young Yhee; Keun Sang Oh; Sohee Son; Sojin Lee; Sun Hwa Kim; Ick Chan Kwon; Kwangmeyung Kim

doi:10.1007/s41061-017-0114-y

Polysaccharide-based Nanoparticles for Gene Delivery

Myung Sook Huh, Eun Jung Lee, Heebeom Koo, Ji Young Yhee, Keun Sang Oh, Sohee Son, Sojin Lee, Sun Hwa Kim, Ick Chan Kwon, Kwangmeyung Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.

Original language	English
Article number	31
Journal	Topics in current chemistry
Volume	375
Issue number	2
DOIs	https://doi.org/10.1007/s41061-017-0114-y
State	Published - 1 Apr 2017

Bibliographical note

Funding Information:
This study was funded by the Global Research Lab (GRL) Project (NRF-2013K1A1A2A02050115), the Global Innovative Research Center (GiRC; NRF-2012K1A1A2A01055811), and the Intramural Research Program of Korea Institute of Science and Technology (KIST).

Publisher Copyright:
© 2017, Springer International Publishing Switzerland.

Keywords

Gene delivery
Nanomedicine
Nanoparticle
Nanotechnology
Polysaccharide
siRNA delivery

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10.1007/s41061-017-0114-y

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abstract = "Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.",

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note = "Funding Information: This study was funded by the Global Research Lab (GRL) Project (NRF-2013K1A1A2A02050115), the Global Innovative Research Center (GiRC; NRF-2012K1A1A2A01055811), and the Intramural Research Program of Korea Institute of Science and Technology (KIST). Publisher Copyright: {\textcopyright} 2017, Springer International Publishing Switzerland.",

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AU - Huh, Myung Sook

AU - Lee, Eun Jung

AU - Koo, Heebeom

AU - Yhee, Ji Young

AU - Oh, Keun Sang

AU - Son, Sohee

AU - Lee, Sojin

AU - Kim, Sun Hwa

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

N1 - Funding Information: This study was funded by the Global Research Lab (GRL) Project (NRF-2013K1A1A2A02050115), the Global Innovative Research Center (GiRC; NRF-2012K1A1A2A01055811), and the Intramural Research Program of Korea Institute of Science and Technology (KIST). Publisher Copyright: © 2017, Springer International Publishing Switzerland.

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N2 - Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.

AB - Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.

KW - Gene delivery

KW - Nanomedicine

KW - Nanoparticle

KW - Nanotechnology

KW - Polysaccharide

KW - siRNA delivery

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ER -

Polysaccharide-based Nanoparticles for Gene Delivery

Abstract

Bibliographical note

Keywords

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