TY - JOUR
T1 - Polymers for bioimaging
AU - Kim, Jong Ho
AU - Park, Kyeongsoon
AU - Nam, Hae Yun
AU - Lee, Seulki
AU - Kim, Kwangmeyung
AU - Kwon, Ick Chan
PY - 2007/8
Y1 - 2007/8
N2 - Many imaging techniques, such as optical imaging, magnetic resonance imaging, nuclear imaging, and ultrasound have been successfully utilized in clinical applications for the past decades. However, there is an urgent need to design new bioimaging probes because imaging of specific molecular pathways in vivo, particularly those that play key roles in disease processes, is hampered by the poor sensitivity and specificity with current low molecular weight imaging compounds. Recently, interdisciplinary research at the interface of polymer chemistry and the bioimaging sciences has led to the generation of polymer-based bioimaging probes for the diagnosis and treatment of disease. A combination of imaging modality and several biocompatible and/or biodegradable synthetic and natural polymers such as multivalent, branched, graft, and block copolymers, polysaccharides and dendrimers, has produced bioimaging probes which have prolonged plasma half-lives, enhanced stability, reduced toxicity, and improved target specificity. Bioimaging facilitates the integration of complex biological phenomena into the rapid visualization process in molecular levels, and are extending the applications into therapy and high throughput drug screening. This review describes the current advances in polymers for bioimaging and highlights their potentials in clinical applications.
AB - Many imaging techniques, such as optical imaging, magnetic resonance imaging, nuclear imaging, and ultrasound have been successfully utilized in clinical applications for the past decades. However, there is an urgent need to design new bioimaging probes because imaging of specific molecular pathways in vivo, particularly those that play key roles in disease processes, is hampered by the poor sensitivity and specificity with current low molecular weight imaging compounds. Recently, interdisciplinary research at the interface of polymer chemistry and the bioimaging sciences has led to the generation of polymer-based bioimaging probes for the diagnosis and treatment of disease. A combination of imaging modality and several biocompatible and/or biodegradable synthetic and natural polymers such as multivalent, branched, graft, and block copolymers, polysaccharides and dendrimers, has produced bioimaging probes which have prolonged plasma half-lives, enhanced stability, reduced toxicity, and improved target specificity. Bioimaging facilitates the integration of complex biological phenomena into the rapid visualization process in molecular levels, and are extending the applications into therapy and high throughput drug screening. This review describes the current advances in polymers for bioimaging and highlights their potentials in clinical applications.
KW - Bioimaging
KW - Conjugation
KW - Imaging probes
KW - Polymer
KW - Targeting
UR - http://www.scopus.com/inward/record.url?scp=34547568983&partnerID=8YFLogxK
U2 - 10.1016/j.progpolymsci.2007.05.016
DO - 10.1016/j.progpolymsci.2007.05.016
M3 - Review article
AN - SCOPUS:34547568983
SN - 0079-6700
VL - 32
SP - 1031
EP - 1053
JO - Progress in Polymer Science
JF - Progress in Polymer Science
IS - 8-9
ER -