Polymeric nanoparticles for protein kinase activity

Jong Ho Kim; Seulki Lee; Kwangmeyung Kim; Hyesung Jeon; Rang Woon Park; In San Kim; Kuiwon Choi; Ick Chan Kwon

doi:10.1039/b612773h

Polymeric nanoparticles for protein kinase activity

Jong Ho Kim, Seulki Lee, Kwangmeyung Kim, Hyesung Jeon, Rang Woon Park, In San Kim, Kuiwon Choi, Ick Chan Kwon

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

Original language	English
Pages (from-to)	1346-1348
Number of pages	3
Journal	Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/b612773h
State	Published - 2007

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@article{a89bef2c491f431f80d2285c10720886,

title = "Polymeric nanoparticles for protein kinase activity",

abstract = "Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.",

author = "Kim, \{Jong Ho\} and Seulki Lee and Kwangmeyung Kim and Hyesung Jeon and Park, \{Rang Woon\} and Kim, \{In San\} and Kuiwon Choi and Kwon, \{Ick Chan\}",

year = "2007",

doi = "10.1039/b612773h",

language = "English",

pages = "1346--1348",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "13",

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TY - JOUR

T1 - Polymeric nanoparticles for protein kinase activity

AU - Kim, Jong Ho

AU - Lee, Seulki

AU - Kim, Kwangmeyung

AU - Jeon, Hyesung

AU - Park, Rang Woon

AU - Kim, In San

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

PY - 2007

Y1 - 2007

N2 - Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

AB - Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

UR - https://www.scopus.com/pages/publications/33947522149

U2 - 10.1039/b612773h

DO - 10.1039/b612773h

M3 - Article

C2 - 17377677

AN - SCOPUS:33947522149

SN - 1359-7345

SP - 1346

EP - 1348

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

Polymeric nanoparticles for protein kinase activity

Abstract

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