Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Seulki Lee; Ju Hee Ryu; Kyeongsoon Park; Aeju Lee; Seung Young Lee; In Chan Youn; Cheol Hee Ahn; Soon Man Yoon; Seung Jae Myung; Dae Hyuk Moon; Xiaoyuan Chen; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim

doi:10.1021/nl902709m

Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Seulki Lee, Ju Hee Ryu, Kyeongsoon Park, Aeju Lee, Seung Young Lee, In Chan Youn, Cheol Hee Ahn, Soon Man Yoon, Seung Jae Myung, Dae Hyuk Moon, Xiaoyuan Chen, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

Original language	English
Pages (from-to)	4412-4416
Number of pages	5
Journal	Nano Letters
Volume	9
Issue number	12
DOIs	https://doi.org/10.1021/nl902709m
State	Published - 9 Dec 2009

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abstract = "We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.",

author = "Seulki Lee and Ryu, {Ju Hee} and Kyeongsoon Park and Aeju Lee and Lee, {Seung Young} and Youn, {In Chan} and Ahn, {Cheol Hee} and Yoon, {Soon Man} and Myung, {Seung Jae} and Moon, {Dae Hyuk} and Xiaoyuan Chen and Kuiwon Choi and Kwon, {Ick Chan} and Kwangmeyung Kim",

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doi = "10.1021/nl902709m",

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T1 - Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

AU - Lee, Seulki

AU - Ryu, Ju Hee

AU - Park, Kyeongsoon

AU - Lee, Aeju

AU - Lee, Seung Young

AU - Youn, In Chan

AU - Ahn, Cheol Hee

AU - Yoon, Soon Man

AU - Myung, Seung Jae

AU - Moon, Dae Hyuk

AU - Chen, Xiaoyuan

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

PY - 2009/12/9

Y1 - 2009/12/9

N2 - We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

AB - We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

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JO - Nano Letters

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Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Abstract

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