Polymeric nanomedicine for cancer therapy

Jae Hyung Park, Seulki Lee, Jong Ho Kim, Kyeongsoon Park, Kwangmeyung Kim, Ick Chan Kwon

Research output: Contribution to journalReview articlepeer-review

474 Scopus citations


Nanomedicine, an offshoot of nanotechnology, refers to highly specific, molecular-scale medical intervention for treating disease or repairing damaged tissues. In recent years, polymer-based nanomedicine, a field that includes the use of polymer-DNA complexes (polyplexes), polymer-drug conjugates, and polymer micelles bearing hydrophobic drugs, has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Owing to their small size and excellent biocompatibility, nanosized polymer therapeutic agents can circulate in the bloodstream for long periods of time, allowing them to reach the target site. In addition, chemical modification of polymer therapeutic agents with ligands capable of specifically binding receptors that are over-expressed in cancer cells can markedly augment therapeutic efficiency. This review highlights the characteristics of cancer that provide nanodrug targeting opportunities and discusses rational approaches for future development of polymeric nanomedicines.

Original languageEnglish
Pages (from-to)113-137
Number of pages25
JournalProgress in Polymer Science
Issue number1
StatePublished - Jan 2008

Bibliographical note

Funding Information:
This research was supported by the KIST intramural “Molecular Imaging Research Project” and by a Grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A062254B8150506N11C011B).


  • Angiogenesis
  • Cancer therapy
  • Drug carrier
  • Polymeric nanomedicine
  • Targeted delivery


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