Polycomb group protein-mediated histone modifications during cell differentiation

Abdul Aziz Khan, Andrew Jeoungun Lee, Tae Young Roh

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Polycomb group (PcG) proteins play an important role in the regulation of gene expression, especially genes encoding lineage-specific factors. Perturbations in PcG protein expression may trigger an unexpected developmental pathway, resulting in birth defects and developmental disabilities. Two Polycomb repressive complexes, PRC1 and PRC2, have been identified and are related with diverse cellular processes through histone modifications. Many developmental genes are trimethylated at histone H3 lysine 27 (H3K27me3) mediated by PRC2, which provides a binding site for PRC1. These processes contribute to chromatin compaction and transcriptional repression. In this review, we discuss about the complex formation of PcG proteins, the mechanism through which they are recruited to target sites and their functional roles in cell differentiation.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalEpigenomics
Volume7
Issue number1
DOIs
StatePublished - 1 Feb 2015

Bibliographical note

Publisher Copyright:
© 2015 Future Medicine Ltd.

Keywords

  • PcG recruitment
  • Polycomb group proteins
  • cell differentiation
  • development
  • homeobox genes

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