Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression

Kyung Ah Cho, Minhwa Park, Yu Hee Kim, Kyung Ha Ryu, So Youn Woo

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

It has been established that mesenchymal stem cells (MSCs) can have a suppressive effect on T cells, yet much remains unknown about the underlying mechanisms that support this effect. The T cell co-stimulatory pathway involving the programmed death-1 (PD-1) receptor and its ligand PD-L1 regulates T cell activation, tolerance, and subsequent immune-mediated tissue damage. In this study, human palatine tonsil-derived MSCs (T-MSCs) constitutively expressed PD-L1 and exhibited a suppressive activity that specifically targeted murine Th17 differentiation. Additionally, polyinosinic–polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs. The elevated PD-L1 levels enhanced the suppressive functions of T-MSCs on Th17 differentiation. Therefore, pre-stimulation of T-MSCs with poly I:C may serve as an effective therapeutic priming step for modulating Th17-dominant immune responses.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalImmunobiology
Volume222
Issue number2
DOIs
StatePublished - 1 Feb 2017

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (No. NRF-2016R1A2B4009182 and 2015R1C1A1A01053573).

Publisher Copyright:
© 2016 Elsevier GmbH

Keywords

  • PD-L1
  • Poly I:C
  • Th17
  • Tonsil-derived MSCs

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