Point-of-care diagnostic tests for tuberculosis disease

Jia Mei Hong, Hyeyoung Lee, Nishanth V. Menon, Chwee Teck Lim, Luke P. Lee, Catherine W.M. Ong

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.

Original languageEnglish
Article numbereabj4124
JournalScience Translational Medicine
Volume14
Issue number639
DOIs
StatePublished - 6 Apr 2022

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