Point-of-care diagnostic tests for tuberculosis disease

Jia Mei Hong; Hyeyoung Lee; Nishanth V. Menon; Chwee Teck Lim; Luke P. Lee; Catherine W.M. Ong

doi:10.1126/scitranslmed.abj4124

Point-of-care diagnostic tests for tuberculosis disease

Jia Mei Hong, Hyeyoung Lee, Nishanth V. Menon, Chwee Teck Lim, Luke P. Lee, Catherine W.M. Ong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.

Original language	English
Article number	eabj4124
Journal	Science Translational Medicine
Volume	14
Issue number	639
DOIs	https://doi.org/10.1126/scitranslmed.abj4124
State	Published - 6 Apr 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 The Authors, some rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/scitranslmed.abj4124

Cite this

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title = "Point-of-care diagnostic tests for tuberculosis disease",

abstract = "Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.",

author = "Hong, {Jia Mei} and Hyeyoung Lee and Menon, {Nishanth V.} and Lim, {Chwee Teck} and Lee, {Luke P.} and Ong, {Catherine W.M.}",

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doi = "10.1126/scitranslmed.abj4124",

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AU - Hong, Jia Mei

AU - Lee, Hyeyoung

AU - Menon, Nishanth V.

AU - Lim, Chwee Teck

AU - Lee, Luke P.

AU - Ong, Catherine W.M.

PY - 2022/4/6

Y1 - 2022/4/6

N2 - Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.

AB - Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.

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JO - Science Translational Medicine

JF - Science Translational Medicine

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M1 - eabj4124

ER -

Point-of-care diagnostic tests for tuberculosis disease

Abstract

Bibliographical note

UN SDGs

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