@article{785acbb88c39459cac6ffdc897b29576,
title = "Point-of-care diagnostic tests for tuberculosis disease",
abstract = "Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.",
author = "Hong, {Jia Mei} and Hyeyoung Lee and Menon, {Nishanth V.} and Lim, {Chwee Teck} and Lee, {Luke P.} and Ong, {Catherine W.M.}",
note = "Funding Information: We were supported by iHealthtech, formerly Biomedical Institute for Global Health Research &Technology (BIGHEART). C.W.M.O. received funding from National University of Singapore (NUHSRO/2017/092/SU/01, CFGFY18P11, iHealthtech) and salary support from the National Medical Research Council, Singapore (NMRC/TA/0042/2015 and CSAINV17nov014). J.M.H. was supported by NUSMed Post-Doctoral Fellowship (NUHSRO/2018/052/PDF/04). H.L. is supported by iHealthtech Scholarship. Publisher Copyright: Copyright {\textcopyright} 2022 The Authors, some rights reserved.",
year = "2022",
month = apr,
day = "6",
doi = "10.1126/scitranslmed.abj4124",
language = "English",
volume = "14",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "639",
}
