Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity

Soo Yeon Lee, Mi Jeong Kim, Subhin Jang, Gyeong Eun Lee, Soo Yeon Hwang, Youngjoo Kwon, Jung Yeon Hong, Myung Hyun Sohn, Soo Yeon Park, Ho Geun Yoon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity. Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases. Plumbagin treatment significantly suppressed transforming growth factor-β-induced profibrotic target-gene expression and proliferation of fibroblast cell lines. Moreover, plumbagin significantly inhibited bleomycin-induced pulmonary fibrosis in mice. Taken together, these data demonstrate the inhibitory effects of plumbagin on lung fibrosis and its promise as a therapeutic agent for IPF.

Original languageEnglish
Pages (from-to)633-640
Number of pages8
JournalJournal of Medicinal Food
Volume23
Issue number6
DOIs
StatePublished - 1 Jun 2020

Keywords

  • histone acetyltransferase
  • p300
  • plumbagin
  • pulmonary fibrosis

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