Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load

Hansol Lee, Yeni Lim, Soo Yeon Park, Soo Muk Cho, Jeong Sook Choe, Sewon Jeong, Jin Sook Kwak, Oran Kwon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

BACKGROUND/OBJECTIVES: Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response to a single dietary fat/sugar load test and monitor beneficial changes induced by the consumption of Platycodi radix (AP) beverage in healthy subjects. SUBJECTS/METHODS: A total of 52 subjects were randomly assigned to either placebo or AP beverage group with a high-fat shake in a randomized controlled crossover trial. Postprandial blood was collected at 0, 1, 2, 4, and 6 h and analyzed for TG and lipoprotein lipase mass. Inhibition of pancreatic lipase was determined in vitro. RESULTS: AP inhibited pancreatic lipase activity in vitro (IC50 = 5 mg/mL). Compared to placebo beverage, AP beverage consumption with a high-fat shake induced significant increase of plasma lipoprotein lipase mass (P = 0.0111, β estimate = 4.2948) with significant reduction in very low-density lipoprotein (VLDL) TG concentration (P = 0.038, β estimate =-52.69) at 6 h. Based on significant correlation between high-fat dietary scores MEDFICTS and postprandial TG responses in VLDL (P = 0.0395, r = 0.2127), subgroup analysis revealed that 6 h-postprandial VLDL TG response was significantly decreased by AP consumption in subjects with MEDFICTS ≥ 40 (P = 0.0291, β estimate =-7214). CONCLUSIONS: AP beverage might have potential to alleviate postprandial lipemia through inhibiting pancreatic lipase activity and elevating lipoprotein lipase mass. Subgroup analysis revealed that subjects with high-fat dietary pattern could be classified as responders to AP beverage among all subjects.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalNutrition Research and Practice
Volume12
Issue number5
DOIs
StatePublished - Oct 2018

Bibliographical note

Funding Information:
This work was carried out with the support of “Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01169503)” funded by Rural Development Administration, Republic of Korea. §Corresponding Author: Oran Kwon, Tel/Fax. 82-2-3277-6860, Email. orank@ewha.ac.kr Received: May 18, 2018, Revised: June 12, 2018, Accepted: July 25, 2018 * These two authors contributed equally to this work. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher Copyright:
© 2018 The Korean Nutrition Society and the Korean Society of Community Nutrition.

Keywords

  • Pancreatic lipase
  • Platycodi radix
  • Postprandial lipemia
  • Randomized controlled trial

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