Platelet shape changes and cytoskeleton dynamics as novel therapeutic targets for anti-thrombotic drugs

Eun Kyung Shin, Hanseul Park, Ji Yoon Noh, Kyung Min Lim, Jin Ho Chung

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or biochemical stimuli, remarkable platelet shape changes precede aggregation or adhesion. Platelets shape changes facilitate the formation and adhesion of platelet aggregates, but are readily reversible in contrast to the irrevocable characteristics of aggregation and adhesion. In this dynamic phenomenon, complex molecular signaling pathways and a host of diverse cytoskeleton proteins are involved. Platelet shape change is easily primed by diverse pro-thrombotic xenobiotics and stimuli, and its inhibition can modulate thrombosis, which can ultimately contribute to the development or prevention of thrombotic diseases. In this review, we discussed the current knowledge on the mechanisms of platelet shape change and also pathological implications and therapeutic opportunities for regulating the related cytoskeleton dynamics.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalBiomolecules and Therapeutics
Volume25
Issue number3
DOIs
StatePublished - May 2017

Keywords

  • Adhesion
  • Aggregation
  • Cytoskeleton dynamics
  • Platelet shape changes
  • Thrombosis

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