Plasma-treated poly(lactic-co-glycolic acid) nanofibers for tissue engineering

Honghyun Park, Kuen Yong Lee, Seung Jin Lee, Ko Eun Park, Won Ho Park

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Nanofibers were prepared by electrospinning a solution of poly (lactic-co-gly colic acid) (PLGA) and their mean diameter was 340 nm. The PLGA nanofibers were treated with a plasma in the presence of either oxygen or ammonia gas to change their surface characteristics. The hydrophilicity of the electrospun PLGA nanofibers was significantly increased by the gas plasma treatment, as confirmed by contact angle measurements. XPS analysis demonstrated that the chemical composition of the PLGA nanofiber surface was influenced by the plasma treatment, resulting in an increase in the number of polar groups, which contributed to the enhanced surface hydrophilicity. The degradation behavior of the PLGA nanofibers was accelerated by the plasma treatment, and the adhesion and proliferation of mouse fibroblasts on the plasma-treated nanofibers were significantly enhanced. This approach to controlling the surface characteristics of nanofibers prepared from biocompatible polymers could be useful in the development of novel polymeric scaffolds for tissue engineering.

Original languageEnglish
Pages (from-to)238-243
Number of pages6
JournalMacromolecular Research
Volume15
Issue number3
DOIs
StatePublished - Apr 2007

Keywords

  • Hydrophilicity
  • Nanofiber
  • Plasma treatment
  • Tissue engineering

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