Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.

Sung Sook Kim, Daewoon Eom, Jooryung Huh, Iel yong Sung, Inpyo Choi, Sung Ho Ryu, Pann Ghill Suh, Sung Min Chung

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Abstract

We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C- gamma 1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.

Original languageEnglish
Pages (from-to)704-707
Number of pages4
JournalJournal of Korean Medical Science
Volume17
Issue number5
DOIs
StatePublished - Oct 2002

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