Pkconverter: R package to convert the pharmacokinetic parameters

Hyeseon Cho, Eun Kyung Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalTranslational and Clinical Pharmacology
Volume27
Issue number2
DOIs
StatePublished - Jun 2019

Keywords

  • Pharmacokinetic model
  • Pharmacokinetic parameter
  • Population analysis
  • R
  • Shiny

Fingerprint

Dive into the research topics of 'Pkconverter: R package to convert the pharmacokinetic parameters'. Together they form a unique fingerprint.

Cite this