Pioneering Effects and Enhanced Neurite Complexity of Primary Hippocampal Neurons on Hierarchical Neurotemplated Scaffolds

Beom Jin Kim, Matthew Park, Ji Hun Park, Sunghoon Joo, Mi Hee Kim, Kyungtae Kang, Insung S. Choi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In this work, the use of scaffolds is reported, templated from live neurons as an advanced culture platform for primary neurons. Hippocampal neurons cultured on neurotemplated scaffolds exhibit an affinity for templated somas, revealing a preference for micrometric structures amidst nanotopographical features. It is also reported, for the first time, that neurite complexity can be topographically controlled by increasing the density of nanometric features on neurotemplated scaffolds. Neurotemplated scaffolds are versatile, hierarchical topographies that feature biologically relevant structures, in both form and scale, and capture the true complexity of an in vivo environment. The introduction and implementation of neurotemplated scaffolds is sure to advance research in the fields of neurodevelopment, network development, and neuroregeneration.

Original languageEnglish
Article number1800289
JournalAdvanced Healthcare Materials
Volume7
Issue number18
DOIs
StatePublished - 19 Sep 2018

Keywords

  • axonal pathfinding
  • hierarchical topographies
  • neurite complexity
  • neurotemplated scaffolds
  • pioneer neurons

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