@article{e24fd2a9376342de8c54378027d59306,
title = "Piezocatalytic 2D WS2 Nanosheets for Ultrasound-Triggered and Mitochondria-Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism-Targeted Chemotherapy",
abstract = "Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as an effective platform for cancer therapy. In this study, piezoelectric 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) for ultrasound (US)-triggered, mitochondria-targeted piezodynamic cancer therapy. In addition, a glycolysis inhibitor (FX11) that can inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol) (PEG)-conjugated WS2 nanosheet (TPEG-WS2) to potentiate its therapeutic efficacy. Upon US irradiation, the sono-excited electrons and holes generated in the WS2 are efficiently separated by piezoelectric polarization, which subsequently promotes the production of ROS. FX11-loaded TPEG-WS2 (FX11@TPEG-WS2) selectively accumulates in the mitochondria of human breast cancer cells. In addition, FX11@TPEG-WS2 effectively inhibits the production of adenosine triphosphate. Thus, FX11@TPEG-WS2 exhibits outstanding anticancer effects under US irradiation. An in vivo study using tumor-xenograft mice demonstrates that FX11@TPEG-WS2 effectively accumulated in the tumors. Its tumor accumulation is visualized using in vivo computed tomography. Notably, FX11@TPEG-WS2 with US irradiation remarkably suppresses the tumor growth of mice without systemic toxicity. This study demonstrates that the combination of piezodynamic therapy and energy metabolism-targeted chemotherapy using mitochondria-targeting 2D WS2 is a novel strategy for the selective and effective treatment of tumors.",
keywords = "WS, glycolysis inhibition, mitochondria targeting, piezodynamic therapy, piezoelectricity",
author = "{Truong Hoang}, Quan and Huynh, {Kim Anh} and {Nguyen Cao}, {Thuy Giang} and Kang, {Ji Hee} and Dang, {Xuan Nghia} and Vasanthan Ravichandran and Kang, {Han Chang} and Minjong Lee and Kim, {Jong Eun} and Ko, {Young Tag} and Lee, {Tae Il} and Shim, {Min Suk}",
note = "Funding Information: Q.T.H., K.A.H., and T.G.N.C. authors contributed equally to this work. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF‐2022R1A2C1007207, NRF‐2020R1A4A2002894). This work was also supported by the Technology Innovation Program (20020733, Development of 11 kW power conversion unit based on nano‐crystalline magnetic material) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). This work was also supported by Korea Basic Science Institute (National research Facilities and Equipment Center) grant funded by the Ministry of Education) (Grant No. 2020R1A6C101A184). All animal studies were carried out according to a protocol approved by the Institutional Animal Care and Use Committee of Incheon National University, South Korea (INU‐ANIM‐2021‐06). Funding Information: Q.T.H., K.A.H., and T.G.N.C. authors contributed equally to this work. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2022R1A2C1007207, NRF-2020R1A4A2002894). This work was also supported by the Technology Innovation Program (20020733, Development of 11 kW power conversion unit based on nano-crystalline magnetic material) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). This work was also supported by Korea Basic Science Institute (National research Facilities and Equipment Center) grant funded by the Ministry of Education) (Grant No. 2020R1A6C101A184). All animal studies were carried out according to a protocol approved by the Institutional Animal Care and Use Committee of Incheon National University, South Korea (INU-ANIM-2021-06). Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",
year = "2023",
month = may,
day = "4",
doi = "10.1002/adma.202300437",
language = "English",
volume = "35",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-Blackwell",
number = "18",
}