Phthalocyanines as medicinal photosensitizers: Developments in the last five years

Xingshu Li; Bing De Zheng; Xiao Hui Peng; Song Zi Li; Jia Wen Ying; Yuanyuan Zhao; Jian Dong Huang; Juyoung Yoon

doi:10.1016/j.ccr.2017.08.003

Phthalocyanines as medicinal photosensitizers: Developments in the last five years

Xingshu Li, Bing De Zheng, Xiao Hui Peng, Song Zi Li, Jia Wen Ying, Yuanyuan Zhao, Jian Dong Huang, Juyoung Yoon

Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

332 Scopus citations

Abstract

Owing to their high extinction coefficients, long absorption wavelengths, and modification tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been widely used as photosensitizers for photodynamic therapy (PDT). Advances made in the past five years on the development of Pcs as medicinal photosensitizers are reviewed and the main design considerations for medicinal applications of these substances are discussed.

Original language	English
Pages (from-to)	147-160
Number of pages	14
Journal	Coordination Chemistry Reviews
Volume	379
DOIs	https://doi.org/10.1016/j.ccr.2017.08.003
State	Published - 15 Jan 2019

Bibliographical note

Funding Information:
This Study was financially supported by the National Natural Science Foundation of China (Grant Nos. 21473033 , 21172037 ), Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 201135141001 ), and a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ).

Funding Information:
This Study was financially supported by the National Natural Science Foundation of China (Grant Nos. 21473033, 21172037), Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 201135141001), and a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814).

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Medicinal
Photodynamic therapy
Photosensitizer
Phthalocyanine
Targeting
Water soluble

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10.1016/j.ccr.2017.08.003

Cite this

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abstract = "Owing to their high extinction coefficients, long absorption wavelengths, and modification tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been widely used as photosensitizers for photodynamic therapy (PDT). Advances made in the past five years on the development of Pcs as medicinal photosensitizers are reviewed and the main design considerations for medicinal applications of these substances are discussed.",

keywords = "Medicinal, Photodynamic therapy, Photosensitizer, Phthalocyanine, Targeting, Water soluble",

author = "Xingshu Li and {De Zheng}, Bing and Peng, {Xiao Hui} and Li, {Song Zi} and Ying, {Jia Wen} and Yuanyuan Zhao and Huang, {Jian Dong} and Juyoung Yoon",

note = "Funding Information: This Study was financially supported by the National Natural Science Foundation of China (Grant Nos. 21473033 , 21172037 ), Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 201135141001 ), and a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ). Funding Information: This Study was financially supported by the National Natural Science Foundation of China (Grant Nos. 21473033, 21172037), Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 201135141001), and a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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AU - Li, Xingshu

AU - De Zheng, Bing

AU - Peng, Xiao Hui

AU - Li, Song Zi

AU - Ying, Jia Wen

AU - Zhao, Yuanyuan

AU - Huang, Jian Dong

AU - Yoon, Juyoung

N1 - Funding Information: This Study was financially supported by the National Natural Science Foundation of China (Grant Nos. 21473033 , 21172037 ), Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 201135141001 ), and a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 ). Funding Information: This Study was financially supported by the National Natural Science Foundation of China (Grant Nos. 21473033, 21172037), Specialized Research Fund for the Doctoral Program of Higher Education (Grant No. 201135141001), and a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). Publisher Copyright: © 2017 Elsevier B.V.

PY - 2019/1/15

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N2 - Owing to their high extinction coefficients, long absorption wavelengths, and modification tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been widely used as photosensitizers for photodynamic therapy (PDT). Advances made in the past five years on the development of Pcs as medicinal photosensitizers are reviewed and the main design considerations for medicinal applications of these substances are discussed.

AB - Owing to their high extinction coefficients, long absorption wavelengths, and modification tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been widely used as photosensitizers for photodynamic therapy (PDT). Advances made in the past five years on the development of Pcs as medicinal photosensitizers are reviewed and the main design considerations for medicinal applications of these substances are discussed.

KW - Medicinal

KW - Photodynamic therapy

KW - Photosensitizer

KW - Phthalocyanine

KW - Targeting

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SP - 147

EP - 160

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

ER -

Phthalocyanines as medicinal photosensitizers: Developments in the last five years

Abstract

Bibliographical note

Keywords

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