Phthalocyanine-Assembled "one-For-Two" Nanoparticles for Combined Photodynamic-Photothermal Therapy of Multidrug-Resistant Bacteria

Rui Wang, Dayeh Kim, Mengyao Yang, Xingshu Li, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The treatment of diseases caused by drug-resistant bacterial infections urgently requires new types of broad-spectrum antimicrobial materials. Herein, we introduce a supramolecular self-assembly, NanoPcN, which realizes the combination of type I photodynamic activity and photothermal effects by modifying zinc(II) phthalocyanine with a 3-(dimethylamino) phenoxy group. Antibacterial experiments demonstrate that this "one-for-two"property endows NanoPcN with excellent antimicrobial efficacy, not only against Gram-positive and Gram-negative bacteria but also against multidrug-resistant bacteria. An ultralow concentration of NanoPcN (50 nM) almost completely inhibited the growth of methicillin-resistant Staphylococcus aureus upon 655 nm laser irradiation (0.5 W/cm2) for 2 min, and the antibacterial effect was significantly stronger than that of the known photosensitizers methylene blue and tetraphenylporphyrin tetrasulfonic acid. Thus, the construction of "one-for-two"materials through a simple molecular structure modification paves a feasible way for the development of effective broad-spectrum antibacterial agents.

Original languageEnglish
Pages (from-to)7609-7616
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number6
StatePublished - 16 Feb 2022


  • multidrug-resistant bacteria
  • one-for-two
  • photodynamic therapy
  • photothermal therapy
  • phthalocyanine self-assembly


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