TY - JOUR
T1 - Phthalocyanine-Assembled "one-For-Two" Nanoparticles for Combined Photodynamic-Photothermal Therapy of Multidrug-Resistant Bacteria
AU - Wang, Rui
AU - Kim, Dayeh
AU - Yang, Mengyao
AU - Li, Xingshu
AU - Yoon, Juyoung
N1 - Funding Information:
X.L. thanks the National Natural Science Foundation of China (grant no. 22078066). J.Y. thanks the National Research Foundation of Korea funded by the Korean government (MSIP) (no. 2012R1A3A2048814) and the Ministry of Education (2021R1A6A1A10039823). We thank the Korea Institute of Basic Science (Western Seoul) for helping us obtain SEM images using a Hitachi, SU8220 field-emission scanning electron microscope.
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/2/16
Y1 - 2022/2/16
N2 - The treatment of diseases caused by drug-resistant bacterial infections urgently requires new types of broad-spectrum antimicrobial materials. Herein, we introduce a supramolecular self-assembly, NanoPcN, which realizes the combination of type I photodynamic activity and photothermal effects by modifying zinc(II) phthalocyanine with a 3-(dimethylamino) phenoxy group. Antibacterial experiments demonstrate that this "one-for-two"property endows NanoPcN with excellent antimicrobial efficacy, not only against Gram-positive and Gram-negative bacteria but also against multidrug-resistant bacteria. An ultralow concentration of NanoPcN (50 nM) almost completely inhibited the growth of methicillin-resistant Staphylococcus aureus upon 655 nm laser irradiation (0.5 W/cm2) for 2 min, and the antibacterial effect was significantly stronger than that of the known photosensitizers methylene blue and tetraphenylporphyrin tetrasulfonic acid. Thus, the construction of "one-for-two"materials through a simple molecular structure modification paves a feasible way for the development of effective broad-spectrum antibacterial agents.
AB - The treatment of diseases caused by drug-resistant bacterial infections urgently requires new types of broad-spectrum antimicrobial materials. Herein, we introduce a supramolecular self-assembly, NanoPcN, which realizes the combination of type I photodynamic activity and photothermal effects by modifying zinc(II) phthalocyanine with a 3-(dimethylamino) phenoxy group. Antibacterial experiments demonstrate that this "one-for-two"property endows NanoPcN with excellent antimicrobial efficacy, not only against Gram-positive and Gram-negative bacteria but also against multidrug-resistant bacteria. An ultralow concentration of NanoPcN (50 nM) almost completely inhibited the growth of methicillin-resistant Staphylococcus aureus upon 655 nm laser irradiation (0.5 W/cm2) for 2 min, and the antibacterial effect was significantly stronger than that of the known photosensitizers methylene blue and tetraphenylporphyrin tetrasulfonic acid. Thus, the construction of "one-for-two"materials through a simple molecular structure modification paves a feasible way for the development of effective broad-spectrum antibacterial agents.
KW - multidrug-resistant bacteria
KW - one-for-two
KW - photodynamic therapy
KW - photothermal therapy
KW - phthalocyanine self-assembly
UR - http://www.scopus.com/inward/record.url?scp=85124291699&partnerID=8YFLogxK
U2 - 10.1021/acsami.1c21891
DO - 10.1021/acsami.1c21891
M3 - Article
C2 - 35112836
AN - SCOPUS:85124291699
SN - 1944-8244
VL - 14
SP - 7609
EP - 7616
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 6
ER -