Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy

Xingshu Li, Dayoung Lee, Jian Dong Huang, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

288 Scopus citations

Abstract

Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via type I photoreactions (i.e., not by 1O2 generation). Herein we demonstrate that a new, nanostructured phthalocyanine assembly, NanoPcA, has the ability to promote highly efficient ROS generation via the type I mechanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications.

Original languageEnglish
Pages (from-to)9885-9890
Number of pages6
JournalAngewandte Chemie - International Edition
Volume57
Issue number31
DOIs
StatePublished - 26 Jul 2018

Bibliographical note

Funding Information:
J.Y. is thankful for financial support from the National Research Foundation of Korea (NRF), which is funded by the Korea government (MSIP) (No. 2012R1A3A2048814). J.H. is thankful for financial support from the National Natural Science Foundation of China (Grants 21473033,U1705282).

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • nanodots
  • photodynamic therapy
  • phthalocyanine
  • reactive oxygen species
  • type I photoreactions

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