pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)

J. Y. Cho; J. Lee; A. Gutowska; B. J. Tarasevich; Y. S. Sohn; B. Jeong

doi:10.1016/s1773-2247(06)50011-5

pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)

J. Y. Cho, J. Lee, A. Gutowska, B. J. Tarasevich, Y. S. Sohn, B. Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared. The polymer showed lower critical solution temperature in water depending on the pH as well as ionic strength. As the temperature increased, the concentrated poly(propylene glycol) aqueous solution precipitated, whereas the concentrated aqueous solution of PA-g-PPG underwent sol-to-gel transition at pH 7.4. The dehydration of poly(propylene glycol) and ionic repulsion of aspartic acid drive gel formation at pH 7.4 over 30-50°C. The PA-g-PPG is expected to be a useful in situ gel forming depot system for drug delivery and tissue engineering applications.

Original language	English
Pages (from-to)	71-76
Number of pages	6
Journal	Journal of Drug Delivery Science and Technology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/s1773-2247(06)50011-5
State	Published - 2006

Keywords

Hydrogel
pH sensitive polymer
Poly(aspartic acid)
Sol-gel transition
Thermosensitive polymer

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10.1016/s1773-2247(06)50011-5

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title = "pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)",

abstract = "A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared. The polymer showed lower critical solution temperature in water depending on the pH as well as ionic strength. As the temperature increased, the concentrated poly(propylene glycol) aqueous solution precipitated, whereas the concentrated aqueous solution of PA-g-PPG underwent sol-to-gel transition at pH 7.4. The dehydration of poly(propylene glycol) and ionic repulsion of aspartic acid drive gel formation at pH 7.4 over 30-50°C. The PA-g-PPG is expected to be a useful in situ gel forming depot system for drug delivery and tissue engineering applications.",

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author = "Cho, {J. Y.} and J. Lee and A. Gutowska and Tarasevich, {B. J.} and Sohn, {Y. S.} and B. Jeong",

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T1 - pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)

AU - Cho, J. Y.

AU - Lee, J.

AU - Gutowska, A.

AU - Tarasevich, B. J.

AU - Sohn, Y. S.

AU - Jeong, B.

PY - 2006

Y1 - 2006

N2 - A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared. The polymer showed lower critical solution temperature in water depending on the pH as well as ionic strength. As the temperature increased, the concentrated poly(propylene glycol) aqueous solution precipitated, whereas the concentrated aqueous solution of PA-g-PPG underwent sol-to-gel transition at pH 7.4. The dehydration of poly(propylene glycol) and ionic repulsion of aspartic acid drive gel formation at pH 7.4 over 30-50°C. The PA-g-PPG is expected to be a useful in situ gel forming depot system for drug delivery and tissue engineering applications.

AB - A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared. The polymer showed lower critical solution temperature in water depending on the pH as well as ionic strength. As the temperature increased, the concentrated poly(propylene glycol) aqueous solution precipitated, whereas the concentrated aqueous solution of PA-g-PPG underwent sol-to-gel transition at pH 7.4. The dehydration of poly(propylene glycol) and ionic repulsion of aspartic acid drive gel formation at pH 7.4 over 30-50°C. The PA-g-PPG is expected to be a useful in situ gel forming depot system for drug delivery and tissue engineering applications.

KW - Hydrogel

KW - pH sensitive polymer

KW - Poly(aspartic acid)

KW - Sol-gel transition

KW - Thermosensitive polymer

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U2 - 10.1016/s1773-2247(06)50011-5

DO - 10.1016/s1773-2247(06)50011-5

M3 - Article

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SN - 1157-1489

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JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

IS - 1

ER -

pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)

Abstract

Keywords

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