TY - JOUR
T1 - Photon-Driven Dye Induction Pyroptosis
T2 - An Emerging Anti-Tumor Immunotherapy Paradigm
AU - Zeng, Shuang
AU - Wang, Jingyun
AU - Kang, Heemin
AU - Li, Haidong
AU - Peng, Xiaojun
AU - Yoon, Juyoung
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2025/1/10
Y1 - 2025/1/10
N2 - Photoimmunotherapy represents a novel and promising modality in anti-tumor immunotherapy, offering new hope in the realm of cancer treatment due to its distinctive mechanism and substantial therapeutic efficacy. This innovative approach synergistically integrates photon technology with immunological principles, utilizing photon energy to activate the body's immune response. Photon-driven pyroptosis, a pivotal element of photoimmunotherapy, has significantly revitalized the advancement of this discipline. To support this critical progress, this minireview offers an exhaustive examination of the organic dyes presently employed for photon-driven pyroptosis, alongside an analysis of the prevailing challenges and opportunities in dye molecule design. It is our aspiration that this minireview will contribute to the acceleration of developments in photon-driven pyroptosis dye and the broader field of photoimmunotherapy.
AB - Photoimmunotherapy represents a novel and promising modality in anti-tumor immunotherapy, offering new hope in the realm of cancer treatment due to its distinctive mechanism and substantial therapeutic efficacy. This innovative approach synergistically integrates photon technology with immunological principles, utilizing photon energy to activate the body's immune response. Photon-driven pyroptosis, a pivotal element of photoimmunotherapy, has significantly revitalized the advancement of this discipline. To support this critical progress, this minireview offers an exhaustive examination of the organic dyes presently employed for photon-driven pyroptosis, alongside an analysis of the prevailing challenges and opportunities in dye molecule design. It is our aspiration that this minireview will contribute to the acceleration of developments in photon-driven pyroptosis dye and the broader field of photoimmunotherapy.
KW - Immunogenic cell death
KW - Photodynamic therapy
KW - Photoimmunotherapy
KW - Photon-driven pyroptosis dye
KW - Photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85211189610&partnerID=8YFLogxK
U2 - 10.1002/anie.202417899
DO - 10.1002/anie.202417899
M3 - Short survey
AN - SCOPUS:85211189610
SN - 1433-7851
VL - 64
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 2
M1 - e202417899
ER -