Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids

Tomonori Kawashima; Kei Ohkubo; Shunichi Fukuzumi

doi:10.1039/b924560j

Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids

Tomonori Kawashima, Kei Ohkubo, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.

Original language	English
Pages (from-to)	994-996
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	8
Issue number	5
DOIs	https://doi.org/10.1039/b924560j
State	Published - 2010

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title = "Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids",

abstract = "UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.",

author = "Tomonori Kawashima and Kei Ohkubo and Shunichi Fukuzumi",

year = "2010",

doi = "10.1039/b924560j",

language = "English",

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journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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T1 - Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids

AU - Kawashima, Tomonori

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

PY - 2010

Y1 - 2010

N2 - UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.

AB - UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.

UR - http://www.scopus.com/inward/record.url?scp=77149128669&partnerID=8YFLogxK

U2 - 10.1039/b924560j

DO - 10.1039/b924560j

M3 - Article

C2 - 20165787

AN - SCOPUS:77149128669

SN - 1477-0520

VL - 8

SP - 994

EP - 996

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 5

ER -

Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids

Abstract

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